NMR structural studies of surfactant protein B, Drs.
This project investigates the structure of the protein SP-B, a lung protein essential for life. This knowledge will be used to improve treatments for common and frequently fatal health conditions such as Acute Respiratory Distress Syndrome, and also may be useful in developing systems for general drug delivery through the lungs. The research will generate better knowledge on the structure of SP-B and how it can improve the treatment of Acute Respiratory Distress Syndrome and general drug delivery through the lungs.
IgniteR&D attracts highly-qualified academic researchers and builds new research and development (R&D) capacity in areas relevant to both industry and the
Assessment of human exposure to flame retardants using size-resolved particle sampling, Dr.
Flame retardant chemicals are added to many household products, such as furniture and electronics, to reduce the risk of fire, but can have negative effects on the environment and human health. Inhalation of atmospheric particles in various locations has been linked to human exposure of these chemicals. This research examines concentrations of flame retardants in indoor and outdoor particles in
Impact of insulin therapy on cardiovascular outcomes in patients with Type 2 diabetes, Dr.
Exposure to high levels of insulin is known to have adverse physiological effects including vascular dysfunction, weight gain, fluid retention, and exacerbation of hypertension. Previous research investigating the cardiovascular effects of insulin has been limited, resulting in the widespread use of anti-diabetic agents that have uncertain cardiovascular effects. This research will provide some of the highest levels of evidence in
Modelling and behaviour of a flexible subsea structure and associated risk, Dr.
The tragic Deep Water Horizon event in 2010 identified a need for faster deployment of containment systems, increased effectiveness of the containment equipment in rough weather, and increased availability of storage capacity (such as barges and tankers) for recovered oil. An alternative approach to solve these challenges is to use a large, flexible membrane structure that would provide a more cost-effective, easy-to-deploy and reliable solution. Before such flexible structures can be implemented, their performance must be predictable. The objective of this research is to develop tools to simulate the behaviour of a flexible structure and develop a risk model for flexible structures under different environmental and operational conditions.
Study of boreal vegetation responses to support economic competitiveness of the forest and agriculture sector, Dr.
Global climate changes affect vegetation dynamics and therefore interfere with recovery of natural resources after natural and anthropogenic disturbances. This research is studying the responses of
Multiphase flow and heat transfer in offshore energy applications, Dr.
A safety challenge in offshore oil and gas operations involves the uncontrolled formation of hydrates. Hydrates are ice-like crystals that can form in subsea pipelines. They affect flow patterns and may lead to flow blockage in a pipeline. This research will develop new methods to better understand and control fluid and heat transfer processes in multiphase flows involving oil, gas, sand and water mixtures for the purpose of improved pipeline safety. Research will be performed on the conditions of pressure, temperature and composition to better predict how hydrates form and grow in cracks and unsmooth surfaces of multiphase subsea pipelines. This research will lead to better control, safety, prediction and understanding of multiphase flows in
System of multisource data fusion for operational ice monitoring, Dr.
C-CORE, an independent not-for-profit R&D corporation housed at
The influence of ocean conditions and species interaction on
Quantifying maximum sustainable yield (MSY) reference points when productivity varies, and marine stewardship, Dr.
Development of a novel risk-based alarm system, Dr.
Industrial operations such as power plants, mining operations, refineries, gas pipelines, and nuclear reactors are inundated with false alarms. Operators must acknowledge hundreds or even thousands of alarms, which are often sounded or displayed simultaneously. This project seeks to reduce the number of false alarms by developing a risk-based system in which individual variables should not be alarmed; instead, alarms will be assigned to indicate specific events. The outcome of this project will use a risk-based approach to help provide industrial plants and their operators with a well-designed alarm system that can provide more effective, accurate and actionable warnings of abnormal situations.
The objective of the research is to quantify the behaviour and life history of groundfish species off
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