A cross-sectional and case-control analysis of physically independent
and physically dependent cohorts of octogenarians: Part one of the life
after 80 study, Dr.
The health, living situations and activity levels are wide ranging for those over the age of 80, the fastest growing population group in
Identification of novel copy number variants (CNVs) using a custom genome-wide microarray chip for diagnosis of familial spondyloarthritis, Dr. Proton Rahman and Dr.
Spondyloarthritis (SpA) represents a collection of chronic inflammatory conditions primarily affecting the spine and peripheral joints. It also exhibits extra-articular features particularly psoriasis, inflammatory bowel disease and uveitis. SpA constitutes a major health challenge because of its prevalence in
Improving cholesterol efflux by targeted disruption of hepatic lipase interactions with the cell surface, Dr.
The blockage of blood vessels is one of the major causes of heart disease, the leading cause of death in the Western world. Existing medications are designed to reduce bad cholesterol and other bad fats in the blood. However, medications are also needed to promote the removal of the cholesterol and bad fats from the vessel walls by good cholesterol (or HDL), and the removal of these fats from the body. This project studies an enzyme with the potential to create more HDL in the blood, and how to modulate the enzyme through the use of engineered molecules. The results of this study may yield a new beneficial treatment against the initiation of blockages in blood vessels.
Mechanisms of molecular regulation of pre-adipocyte differentiation by CD24, Dr.
Weight loss in obese individuals can be very difficult to achieve and/or maintain by lifestyle changes alone. Conversely, treatments for fat-wasting conditions, including lipodystrophia and cancer-associated cachexia, have had limited success. Therefore, development of targeted therapies is essential to address both the excess and lack of fat tissue. This project investigates how the development of precursor cells to mature fat cells is controlled. The long-term goal is to develop non-invasive, and potentially long-lasting therapies that could reduce the amount of fat tissue in obese individuals. This research may help to design drugs for maintenance of a healthy amount of fat.
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