XenoPort also announced that it has completed 13-week toxicology studies of XP23829 in three species. Each study included a dose of DMF chosen to provide a similar MMF exposure to that of the highest dose of XP23829. The adverse effects of XP23829 were similar to those of DMF, except for fewer and less severe adverse effects in the stomach after dosing XP23829. The target organs for XP23829 were identical to DMF, and there was no increase in severity of any adverse effects for XP23829 compared with DMF. These preliminary results support a conclusion that all observed adverse effects of XP23829 were attributable to exposure to MMF, the common active metabolite of DMF and XP23829.
"In addition to advancing XP23829 development, we believe these new studies have generated important new intellectual property," stated Dr. Barrett. "Over the last five years, XenoPort scientists have generated immense knowledge and experience concerning prodrugs of MMF. This has resulted in the broad filing of 15 patent applications that cover composition of matter, methods of synthesis, crystalline forms, improved formulations, methods to achieve desired PK profiles and methods to improve tolerability, that in some cases are applicable to MMF prodrugs in general. We believe we are in a leadership position with regard to development of patent-protected, next-generation fumaric-acid ester medicines." Conference Call XenoPort will host a conference call at 5:00 p.m. Eastern Time today to discuss its XP23829 study results. To access the conference call via the Internet, go to www.XenoPort.com. To access the live conference call via phone, dial 1-888-275-3514. International callers may access the live call by dialing 706-679-1417. The reference number to enter the call is 58004727.
The replay of the conference call will be available for one week and may be accessed after 8:00 p.m. Eastern Time today via the Internet, at www.XenoPort.com, or via phone at 1-855-859-2056 for domestic callers, or 404-537-3406 for international callers. The reference number to enter the replay of the call is 58004727. About XenoPort XenoPort, Inc. is a biopharmaceutical company focused on developing and commercializing a portfolio of internally discovered product candidates for the potential treatment of neurological disorders. XenoPort is currently commercializing HORIZANT® (gabapentin enacarbil) Extended-Release Tablets in the United States and developing its novel fumaric acid ester product candidate, XP23829, as a potential treatment for RRMS and/or psoriasis. REGNITE® (gabapentin enacarbil) Extended-Release Tablets is being marketed in Japan by Astellas Pharma Inc.XenoPort's pipeline of product candidates also includes potential treatments for patients with spasticity related to spinal cord injury and Parkinson's disease. To learn more about XenoPort, please visit the company Website at www.XenoPort.com.
Keywords for this news article include: Therapy, Treatment, XenoPort Inc, Adverse Drug Reaction.
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