Deng believes that replacing glial cells with the enhanced spiking OPCs to treat neural injuries and diseases has the potential to be a better strategy than replacing neurons, which tend to be more problematic to work with. Providing the proper structure and environment for neurons to live may be the best approach to regenerate healthy neural tissue. He also notes that many diverse conditions that have not traditionally been considered to be myelin-related diseases - including schizophrenia, epilepsy and amyotrophic lateral sclerosis (ALS) - actually are now recognized to involve defective myelin.
The article, titled 'Generation and characterization of spiking and non-spiking oligodendroglial progenitor cells from embryonic stem cells,' is available online at http://www.ncbi.nlm.nih.gov/pubmed/23940003 in the journal Stem Cells.
Other study authors affiliated with the
This research was supported by grants from the
For more information, visit www.ucdmc.ucdavis.edu/stemcellresearch.
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