"Applying the second geometric shape may also include fitting a curve through the anatomical landmark. For example, the method may include fitting a parabola through the scleral spur. The method may also include using the outline to locate a second point and third point. Fitting the curve may also include fitting the parabola through the scleral spur and the third point.
"In addition, the method may include locating a fourth point positioned above a straight line extending through the scleral spur and the third point. And, the method may fit the parabola through the scleral spur, the third point and the fourth point. The parabola, for example, may define an upper boundary between the ciliary boundary and the sclera.
"The parabola may be adjusted by minimizing the energy of the image data. The parabola may also be adjusted using a least squares fit.
"The method may also include applying different indexes of refraction to the sclera and the ciliary body.
"The method may also include removing the iris from the image using the second point and the scleral spur.
"Also, the method may include measuring one or more characteristics of the ciliary body, such as the thickness, area, volume, etc.
BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS
"FIG. 1A is an image of a scleral spur with caliper determination of a desired measurement distance from the scleral spur;
"FIG. 1B is an image of another scleral spur with caliper determination of a desired measurement distance from the scleral spur;
"FIG. 2 is a schematic or flow diagram of a method or process for measuring a ciliary body;
"FIG. 3 is a Visante.TM. image of the front surface of an optical flat (bright white line);
"FIG. 4A is a photograph of a human donor sclera and body tissue with outlined anatomical structures;
"FIG. 4B is a Visante.TM. image of the sclera of FIG. 4A with outlined anatomical structures;
"FIG. 4C is a registration of the outlined anatomical structures of FIG. 4B onto the photograph of FIG. 4A;
"FIG. 5 is an image of a ciliary body showing three software caliper measurements, i.e., at 1 mm (CBT1), 2 mm (CBT2), and 3 mm (CBT3) posterior to the scleral spur;
"FIG. 6 is an example of an image of the ciliary body that was exported from the Visante.TM. as a binary file;
"FIGS. 7A-7D illustrate segmentation of the ciliary body and sclera from background information;
"FIGS. 8A-8C illustrate segmentation of the ciliary body from the sclera;
"FIG. 9 illustrates measurements being made of the ciliary body from FIGS. 8A-8C;
"FIG. 10 illustrates the relationship between the number of images and interclass correlation between measurements;
"FIG. 11 illustrates the results of an experimental comparison between caliper measurements and measurements made using the present method; and
"FIG. 12 is a schematic of a computer system for implementing a method of the present invention."
For more information, see this patent application: Bailey, Melissa D.; Kao, Chiu-Yen. Detection and Measurement of Tissue Images. U.S. Patent Application Serial Number 757243, filed
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