Necrosis is the outcome of severe and acute injury. It is involved in many pathological conditions such as heart attack, brain injuries and stroke, neurodegenerative diseases such as Alzheimer's dementia, Lou Gehrig's disease (ALS), septic shock, liver cirrhosis, chronic hepatitis, pancreatitis, diabetes, acute or critical limb ischemia, gangrene, chronic pressure ulcers and many others. Necrosis occurs following ischemia (a shortage of oxygen supply to the tissue due to restriction in blood supply). The only treatment available at present for necrosis is providing oxygen by a high pressure facility. Thus, there is a crucial need to develop drugs for prevention and treatment of this pathology.
For decades, oxygen carriers have been developed for perfusion and oxygenation of ischemic tissue; none have yet succeeded. These products were either blood-derived elements, synthetic perfluorocarbons or red blood cell modifiers. Several of the Hemoglobin-Based Oxygen Carriers (HBOC) contained nonfunctional methemoglobin impurities. These products failed to secure FDA approval based upon either poor outcomes in clinical trials or poorly formulated product.
The new approach to treatment of ischemic tissue and prevention of necrosis is fundamentally different; it is a New Chemical Entity (NCE), not a biologic blood substitute, with a modified Heme chemical structure.
In summary, the report points out that the complex carbohydrate chemistry, as it is being harnessed by Boston Therapeutics, is a key tool for addressing unmet medical needs in a variety of areas. Its continued development might offer new treatments and hope for millions of patients worldwide.
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