Approximately 60 percent of patients with type 2 diabetes in the United States are obese, while another 30 percent are overweight. In most people at risk for type 2 diabetes, obesity causes the body to resist the action of insulin, and if the pancreatic beta cell cannot produce enough insulin, hyperglycemia and type 2 diabetes ensue. If left uncontrolled, type 2 diabetes can lead to serious complications; improved glycemic control has been demonstrated to reduce the onset and progression of these complications.1
WHAT IS INVOKANA™?
•INVOKANA™ is a prescription medicine used along with diet and exercise to lower blood sugar in adults with type 2 diabetes.
•INVOKANA™ is not for people with type 1 diabetes.
•INVOKANA™ is not for people with diabetic ketoacidosis (increased ketones in blood or urine).
•It is not known if INVOKANA™ is safe and effective in children under 18 years of age.
IMPORTANT SAFETY INFORMATION
WHAT IS THE MOST IMPORTANT INFORMATION I SHOULD KNOW ABOUT INVOKANA™?
INVOKANA™ can cause important side effects, including:
•Dehydration. INVOKANA™ can cause some people to have dehydration (the loss of body water and salt). Dehydration may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand up (orthostatic hypotension).
You may be at higher risk of dehydration if you:
•have low blood pressure
•take medicines to lower your blood pressure, including diuretics (water pill)
•are on low sodium (salt) diet
•have kidney problems
•are 65 years of age or older
•Vaginal yeast infection. Women who take INVOKANA™ may get vaginal yeast infections. Symptoms of a vaginal yeast infection include:
•white or yellowish vaginal discharge (discharge may be lumpy or look like cottage cheese)
•Yeast infection of the penis (balanitis or balanoposthitis). Men who take INVOKANA™ may get a yeast infection of the skin around the penis. Certain men who are not circumcised may have swelling of the penis that makes it difficult to pull back the skin around the tip of the penis. Other symptoms of yeast infection of the penis include:
•redness, itching, or swelling of the penis
•rash of the penis
•foul smelling discharge from the penis
•pain in the skin around penis
Talk to your doctor about what to do if you get symptoms of a yeast infection of the vagina or penis. Your doctor may suggest you use an over-the-counter antifungal medicine. Talk to your doctor right away if you use an over-the-counter antifungal medication and your symptoms do not go away.
WHO SHOULD NOT TAKE INVOKANA™?
Do not take INVOKANA™ if you:
•are allergic to canagliflozin or any of the ingredients in INVOKANA™. See the end of the Medication Guide for a list of ingredients in INVOKANA™. Symptoms of allergic reaction to INVOKANA™ may include:
•raised red patches on your skin (hives)
•swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing
•have severe kidney problems or are on dialysis
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