About Rheumatoid Arthritis
Rheumatoid Arthritis (RA) is a chronic disease that causes pain, stiffness and swelling, primarily in the joints. RA affects approximately 1.8 million people in the U.S. and is not associated with factors such as aging. Worldwide, RA has an estimated prevalence of 0.3 to 1% of the total adult population.
RA occurs when the body's immune system malfunctions, attacking healthy tissue and causing inflammation, which leads to pain and swelling in the joints and may eventually cause permanent joint damage and painful disability. The primary symptoms of RA include progressive immobility and pain, especially in the morning, with long-term sufferers experiencing continual joint destruction for the remainder of their lives.
About Ankylosing Spondylitis
Ankylosing spondylitis (AS) is a chronic, progressive, connective tissue disorder that is characterized by inflammation of the joints of the spine (vertebral joints), hipbones, and sacrum (sacroiliac joints). Symptoms of AS are similar to those of RA, including pain, swelling and stiffness in the affected joints. The disorder differs from RA in that spondylitis primarily affects the spine, forming bony outgrowths (syndesmophytes) between the vertebrae, which may fuse vertebrae and lead to total spinal immobility (ankylosis). The worldwide annual incidence of AS is estimated to be up to 7.3 per 100,000 individuals. DUEXIS is not approved for the treatment of AS in the United States.
About Horizon Pharma
Horizon Pharma, Inc. is a specialty pharmaceutical company that has developed and is commercializing DUEXIS and RAYOS/LODOTRA, both of which target unmet therapeutic needs in arthritis, pain and inflammatory diseases. The Company's strategy is to develop, acquire, in-license and/or co-promote additional innovative medicines where it can execute a targeted commercial approach in specific therapeutic areas while taking advantage of its commercial strengths and the infrastructure the Company has put in place. For more information, please visit www.horizonpharma.com.
Forward Looking Statements
This press release contains forward-looking statements, including statements regarding Horizon's plans to find commercial partners for DUEXIS in Europe and expectations of market opportunities for DUEXIS. These forward-looking statements are based on management's expectations and assumptions as of the date of this press release and actual results may differ materially from those in these forward-looking statements as a result of various factors, including, but not limited to, risks regarding Horizon's ability to commercialize products successfully or to find partners to help it commercialize its products in Europe. For a further description of these and other risks facing Horizon, please see the risk factors described in Horizon's filings with the United States Securities and Exchange Commission, including those factors discussed under the caption "Risk Factors" in those filings. Forward-looking statements speak only as of the date of this press release and Horizon undertakes no obligation to update or revise these statements, except as may be required by law.
Robert J. De Vaere
Executive Vice President and Chief Financial Officer
Burns McClellan, Inc.
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