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It also will monitor the National Intelligence Council's preparation of the first-ever national intelligence estimate on the global risk of mass atrocities and genocide and will work with the director of national intelligence to include information about mass atrocity threats in the annual threat assessment to Congress.
"Across government, alert channels will ensure that information about unfolding crises and dissenting opinions quickly reach decision makers, including me," Obama said.
He said that the Treasury Department will work to more quickly deploy financial tools to block the flow of money to abusive regimes and that the State Department would improve its ability to "surge our diplomats and experts in a crisis."
And he said the U.S. Agency for International Development will challenge high-tech companies to help create new technologies to quickly expose violations of human rights.
"We need to be doing everything we can to prevent and respond to these kinds of atrocities because national sovereignty is never a license to slaughter your people," Obama said.
He also announced that the U.S. will continue to deploy U.S. military advisers to assist Uganda and other regional African forces that are pursuing the murderous Lord's Resistance Army, led by rebel Joseph Konya.
He called it part of a "regional strategy to end the scourge that is the LRA and help realize a future where no African child is stolen from their family and no girl is raped and no boy is turned into a child soldier."
He noted that later this spring he will posthumously award the Presidential Medal of Freedom to Jan Karaka, a young Polish Catholic "who witnessed Jews being put on cattle cars, who saw the killings, and who told the truth, all the way to President Roosevelt himself."
Obama also used his speech to defend his policy toward Iran, which has come under criticism from his Republican rivals, who accuse him of failing to convince the country to abandon its quest for nuclear weapons. Analysts, however, have said that the administration has imposed some of the toughest sanctions against Iran in the regime's history.
Campaigning in Pennsylvania ahead of Tuesday's primary, Republican presidential front-runner Mitt Romney called Obama's approach to Iran one of his great failings.
"When he came into office he should have put into place aggressive, crippling sanctions against Iran," he said. "And then over the last year or two he's been acting like he's more concerned that Israel might take action to get rid of (Iran's) nuclear weapons than he is about Iran developing nuclear weapons."
Obama told the crowd at the museum, which included Holocaust survivors, that he's promised he will "always be there for Israel."
"When faced with a regime that threatens global security and denies the Holocaust and threatens to destroy Israel, the United States will do everything in our power to prevent Iran from getting a nuclear weapon," he said.
Human rights groups applauded the focus on genocide prevention.
"This new 'all of government approach' reflects hard-learned lessons from tardy responses to past humanitarian crises," said Frank Jannuzi, Amnesty International USA's deputy executive director for advocacy, policy and research.
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