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New Nanoparticles Findings from Central Research Laboratory Discussed (Subchronic Toxicity of Copper Oxide Nanoparticles and Its Attenuation with the...

September 12, 2014



New Nanoparticles Findings from Central Research Laboratory Discussed (Subchronic Toxicity of Copper Oxide Nanoparticles and Its Attenuation with the Help of a Combination of Bioprotectors)

By a News Reporter-Staff News Editor at Science Letter -- Researchers detail new data in Nanoparticles. According to news reporting originating from Ekaterinburg, Russia, by NewsRx correspondents, research stated, "In the copper metallurgy workplace air is polluted with condensation aerosols, which a significant fraction of is presented by copper oxide particles

Our news editors obtained a quote from the research from Central Research Laboratory, "A stable suspension of copper oxide particles with mean (+/- SD) diameter 20 +/- 10 nm was prepared by laser ablation of pure copper in water. It was being injected intraperitoneally to rats at a dose of 10 mg/kg (0.5 mg per mL of deionized water) three times a week up to 19 injections. In parallel, another group of rats was so injected with the same suspension against the background of oral administration of a. bio-protective complex. (BPC) comprising pectin, a multivitamin-multimineral preparation, some amino acids and fish oil rich in omega-3 PUFA. After the termination of injections, many functional and biochemical indices for the organism's status, as well as pathological changes of liver, spleen, kidneys, and brain microscopic structure were evaluated for signs of toxicity. In the same organs we have measured accumulation of copper while their cells were used for performing the Random Amplification of Polymorphic DNA (RAPD) test for DNA fragmentation. The same features were assessed in control rats infected intraperitoneally with water with or without administration of the BPC. The copper oxide nanoparticles proved adversely bio-active in all respects considered in this study, their active in vivo solubilization in biological fluids playing presumably an important role in both toxicokinetics and toxicodynamics. The BPC proposed and tested by us attenuated systemic and target organs toxicity, as well as genotoxicity of this substance."

According to the news editors, the research concluded: "Judging by experimental data obtained in this investigation, occupational exposures to nano-scale copper oxide particles can present a significant health risk while the further search for its management with the help of innocuous bioprotectors seems to be justified."

For more information on this research see: Subchronic Toxicity of Copper Oxide Nanoparticles and Its Attenuation with the Help of a Combination of Bioprotectors. International Journal of Molecular Sciences, 2014;15(7):12379-12406. International Journal of Molecular Sciences can be contacted at: Mdpi Ag, Postfach, Ch-4005 Basel, Switzerland (see also Nanoparticles).

The news editors report that additional information may be obtained by contacting L.I. Privalova, Ural State Med Univ, Cent Res Lab, Ekaterinburg 630109, Russia. Additional authors for this research include B.A. Katsnelson, N.V. Loginova, V.B. Gurvich, V.Y. Shur, I.E. Valamina, O.H. Makeyev, M.P. Sutunkova, I.A. Minigalieva, E.P. Kireyeva, V.O. Rusakov, A.E. Tyurnina, R.V. Kozin, E.Y. Meshtcheryakova, A.V. Korotkov and E. Shuman.

Keywords for this news article include: Ekaterinburg, Russia, Eurasia, Emerging Technologies, Nanoparticle, Nanoparticles, Nanotechnology

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Science Letter


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