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Findings from Rice University in DNA Research Reported (Directing Assembly of DNA-Coated Colloids with Magnetic Fields To Generate Rigid,...

September 12, 2014



Findings from Rice University in DNA Research Reported (Directing Assembly of DNA-Coated Colloids with Magnetic Fields To Generate Rigid, Semiflexible, and Flexible Chains)

By a News Reporter-Staff News Editor at Science Letter -- New research on DNA Research is the subject of a report. According to news reporting originating in Houston, Texas, by NewsRx journalists, research stated, "We report the formation of colloidal macromolecules consisting of chains of micron-sized paramagnetic particles assembled using a magnetic field and linked with DNA. The interparticle spacing and chain flexibility were controlled by varying the magnetic field strength and the linker spring constant."

The news reporters obtained a quote from the research from Rice University, "Variations in the DNA lengths allowed for the generation of chains with an improved range of flexibility as compared to previous studies. These chains adopted the rigid-rod, semiflexible, and flexible conformations that are characteristic of linear polymer systems. These assembly techniques were investigated to determine the effects of the nanoscale DNA linker properties on the properties of the microscale colloidal chains. With stiff DNA linkers (564 base pairs) the chains were only stable at moderate to high field strengths and produced rigid chains. For flexible DNA linkers (8000 base pairs), high magnetic field strengths caused the Linkers to be excluded from the gap between the particles, leading to a transition from very flexible chains at low field strengths to semiflexible chains at high field strengths. In the intermediate range of linker sizes, the chains exhibited predictable behavior, demonstrating increased flexibility with longer DNA linker length or smaller linking field strengths."

According to the news reporters, the research concluded: "This study provides insight into the process of directed assembly using magnetic fields and DNA by precisely tuning the components to generate colloidal analogues of linear macromolecular chains."

For more information on this research see: Directing Assembly of DNA-Coated Colloids with Magnetic Fields To Generate Rigid, Semiflexible, and Flexible Chains. Langmuir, 2014;30(30):9045-9052. Langmuir can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Langmuir - www.pubs.acs.org/journal/langd5)

Our news correspondents report that additional information may be obtained by contacting J. Byrom, Rice University, Dept. of Chem & Biomol Engn, Houston, TX 77005, United States. Additional authors for this research include P. Han, M. Savory and S.L. Biswal (see also DNA Research).

Keywords for this news article include: Houston, Texas, United States, North and Central America, DNA Research

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Science Letter


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