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Findings from Johns Hopkins University Provides New Data about Endometrial Cancer (A comparison of colorimetric versus fluorometric sentinel lymph...

September 8, 2014



Findings from Johns Hopkins University Provides New Data about Endometrial Cancer (A comparison of colorimetric versus fluorometric sentinel lymph node mapping during robotic surgery for endometrial cancer)

By a News Reporter-Staff News Editor at Robotics & Machine Learning -- Investigators publish new report on Oncology. According to news originating from Baltimore, Maryland, by VerticalNews correspondents, research stated, "The study objective was to compare the ability to detect sentinel lymph nodes (SLNs) in women with endometrial cancer (EC) or complex atypical hyperplasia (CAH) using fluorometric imaging with indocyanine green (ICG) versus colorimetric imaging with isosulfan blue (ISB). Women underwent SLN mapping, with either ISB or ICG, during robotic-assisted total laparoscopic hysterectomy (RA-TLH) from September 2012 to March 2014."

Our news journalists obtained a quote from the research from Johns Hopkins University, "SLNs were submitted for permanent pathologic analysis. Completion lymphadenectomy and ultrastaging were performed according to institutional protocols. RA-TLH and SLN mapping was performed in 71 women; 64 had EC (64) and 7 had CAH. Age, body mass index (BMI), stage and tumor characteristics were similar in the ICG versus the ISB cohorts. Overall, SLNs were-identified bilaterally (62.0%), unilaterally (21.1%), or neither (16.9%), and in 103 of 142 hemi-pelvises (72.5%). The mean number of SLNs retrieved per hemipelvis was 2.23 (SD 1.7). SLNs were identified in the hypogastric (76.8%), external iliac (14.2%), common iliac (4.5%) and paraaortic (4.5%) regions. ICG mapped bilaterally in 78.9% of women compared with 42.4% of those injected with ISB (p = 0.02). Five women (7%) had positive lymph nodes, all identified by the SLN protocol (false negative rate: 0%). On multivariate analysis, BMI was negatively correlated with bilateral mapping success (p = 0.02). When stratified by dye type, the association with BMI was only significant for ISB (p = 0.03). Fluorescence imaging with ICG may be superior to colorimetric imaging with ISB in women undergoing SLN mapping for endometrial cancer."

According to the news editors, the research concluded: "SLN mapping success is negatively associated with increasing patient BMI only when ISB is used."

For more information on this research see: A comparison of colorimetric versus fluorometric sentinel lymph node mapping during robotic surgery for endometrial cancer. Gynecologic Oncology, 2014;134(2):281-286. Gynecologic Oncology can be contacted at: Academic Press Inc Elsevier Science, 525 B St, Ste 1900, San Diego, CA 92101-4495, USA. (Elsevier - www.elsevier.com; Gynecologic Oncology - www.elsevier.com/wps/product/cws_home/622840)

The news correspondents report that additional information may be obtained from A.K. Sinno, Johns Hopkins University, Dept. of Gynecol & Obstet, Kelly Gynecol Oncol Serv, Baltimore, MD 21287, United States. Additional authors for this research include A.N. Fader, K.L. Roche, R.L. Giuntoli and E.J. Tanner.

Keywords for this news article include: Baltimore, Maryland, United States, North and Central America, Emerging Technologies, Endometrial Cancer, Gynecology, Hemic and Immune Systems, Lymph Nodes, Machine Learning, Oncology, Robotics, Robots, Surgery, Women's Health

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Robotics & Machine Learning


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