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Study Findings on Analytical Toxicology Are Outlined in Reports from P. Amaratunga and Colleagues (Quantitative Measurement of XLR11 and UR-144 in...

September 9, 2014



Study Findings on Analytical Toxicology Are Outlined in Reports from P. Amaratunga and Colleagues (Quantitative Measurement of XLR11 and UR-144 in Oral Fluid by LC-MS-MS)

By a News Reporter-Staff News Editor at Life Science Weekly -- Data detailed on Life Science Research have been presented. According to news reporting originating from Kalamazoo, Michigan, by NewsRx correspondents, research stated, "Availability and consumption of synthetic cannabinoids have risen recently in the USA and Europe. These drugs have adverse effects, including acute psychosis and bizarre behavior."

Our news editors obtained a quote from the research, "In 2012, the United States Drug Enforcement Agency permanently banned five of the synthetic cannabinoids and in 2013, temporarily added XLR11, UR-144 and AKB48 to Schedule I of the Controlled Substances Act. As synthetic cannabinoid strains are added to the Schedule I list, new strains are being introduced into the market. XLR11 and UR-144 are two of the most recent additions to the synthetic cannabinoid drug class. To test collected oral fluid samples for XLR11 and UR-144, we developed a bioanalytical method that initially purifies the sample with solid-phase extraction and then quantitatively identifies the drugs with ultra-high-performance liquid chromatography-tandem mass spectrometry. The method was validated according to United States Food and Drug Administration guidelines and Scientific Working Group for Forensic Toxicology guidelines and the validation data showed that the method is an accurate, precise, robust and efficient method suited for high-throughput toxicological screening applications."

According to the news editors, the research concluded: "We tested human subject samples with the developed method and found the presence of parent drugs (XLR11 and UR-144), their metabolites and their pyrolysis products in oral fluid."

For more information on this research see: Quantitative Measurement of XLR11 and UR-144 in Oral Fluid by LC-MS-MS. Journal of Analytical Toxicology, 2014;38(6):315-321. Journal of Analytical Toxicology can be contacted at: Oxford Univ Press Inc, Journals Dept, 2001 Evans Rd, Cary, NC 27513, USA. (Oxford University Press - www.oup.com/; Journal of Analytical Toxicology - jat.oxfordjournals.org)

The news editors report that additional information may be obtained by contacting P. Amaratunga, Forens Fluids Labs, Kalamazoo, MI 49009, United States. Additional authors for this research include C. Thomas, B.L. Lemberg and D. Lemberg (see also Life Science Research).

Keywords for this news article include: Kalamazoo, Michigan, United States, North and Central America, Life Science Research

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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