Study Data from Bambino Gesu Pediatric Hospital Update Understanding of Glycogen Storage Disease (Immune Tolerance Induced Using Plasma Exchange and Rituximab in an Infantile Pompe Disease Patient)
By a News Reporter-Staff News Editor at Biotech Week -- Fresh data on Nutritional and Metabolic Diseases and Conditions are presented in a new report. According to news originating from Rome, Italy, by NewsRx correspondents, research stated, "Infantile Pompe disease, resulting from deficiency of lysosomal acid alpha-glucosidase, requires enzyme replacement therapy with recombinant human acid alpha-glucosidase. Most patients develop antirecombinant human acid alpha-glucosidase antibodies, leading to reduced response to enzyme therapy in a subgroup of them."
Our news journalists obtained a quote from the research from Bambino Gesu Pediatric Hospital, "Aiming to improve treatment response, several immune tolerance induction strategies have been explored. We describe a patient with life-threatening infusion-associated reactions presenting antirecombinant human acid alpha-glucosidase antibodies. He was successfully treated with an immune tolerance induction protocol, consisting of plasma exchange combined with a single dose of rituximab. Immediate reduction of antibody titer was obtained and enzyme therapy was resumed without infusion-associated reactions. Twenty-two months later, immunoglobulin G titer remained below 1:100."
According to the news editors, the research concluded: "We applied a short-course immune tolerance induction strategy in a patient with severe infusion-associated reactions and anti-recombinant human acid alpha-glucosidase antibodies, leading to early and persisting reduction of antibody titer, in the absence of significant adverse events."
For more information on this research see: Immune Tolerance Induced Using Plasma Exchange and Rituximab in an Infantile Pompe Disease Patient. Journal of Child Neurology, 2014;29(6):850-854. Journal of Child Neurology can be contacted at: Sage Publications Inc, 2455 Teller Rd, Thousand Oaks, CA 91320, USA. (Sage Publications - www.sagepub.com/; Journal of Child Neurology - jcn.sagepub.com)
The news correspondents report that additional information may be obtained from F. Deodato, Bambino Gesu Pediat Hosp, Dept. of Pediat Cardiol, IRCCS, I-00165 Rome, Italy. Additional authors for this research include V.M. Ginocchio, A. Onofri, G. Grutter, A. Germani and C. Dionisi-Vici (see also Nutritional and Metabolic Diseases and Conditions).
Keywords for this news article include: Rome, Italy, Europe, Antibodies, Blood Proteins, Enzymes and Coenzymes, Glucosidases, Glycogen Storage Disease, Glycoside Hydrolases, Immunoglobulins, Immunology, Nutritional and Metabolic Diseases and Conditions, Therapy
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC