News Column

Study Data from Bambino Gesu Pediatric Hospital Update Understanding of Glycogen Storage Disease (Immune Tolerance Induced Using Plasma Exchange and...

September 10, 2014



Study Data from Bambino Gesu Pediatric Hospital Update Understanding of Glycogen Storage Disease (Immune Tolerance Induced Using Plasma Exchange and Rituximab in an Infantile Pompe Disease Patient)

By a News Reporter-Staff News Editor at Biotech Week -- Fresh data on Nutritional and Metabolic Diseases and Conditions are presented in a new report. According to news originating from Rome, Italy, by NewsRx correspondents, research stated, "Infantile Pompe disease, resulting from deficiency of lysosomal acid alpha-glucosidase, requires enzyme replacement therapy with recombinant human acid alpha-glucosidase. Most patients develop antirecombinant human acid alpha-glucosidase antibodies, leading to reduced response to enzyme therapy in a subgroup of them."

Our news journalists obtained a quote from the research from Bambino Gesu Pediatric Hospital, "Aiming to improve treatment response, several immune tolerance induction strategies have been explored. We describe a patient with life-threatening infusion-associated reactions presenting antirecombinant human acid alpha-glucosidase antibodies. He was successfully treated with an immune tolerance induction protocol, consisting of plasma exchange combined with a single dose of rituximab. Immediate reduction of antibody titer was obtained and enzyme therapy was resumed without infusion-associated reactions. Twenty-two months later, immunoglobulin G titer remained below 1:100."

According to the news editors, the research concluded: "We applied a short-course immune tolerance induction strategy in a patient with severe infusion-associated reactions and anti-recombinant human acid alpha-glucosidase antibodies, leading to early and persisting reduction of antibody titer, in the absence of significant adverse events."

For more information on this research see: Immune Tolerance Induced Using Plasma Exchange and Rituximab in an Infantile Pompe Disease Patient. Journal of Child Neurology, 2014;29(6):850-854. Journal of Child Neurology can be contacted at: Sage Publications Inc, 2455 Teller Rd, Thousand Oaks, CA 91320, USA. (Sage Publications - www.sagepub.com/; Journal of Child Neurology - jcn.sagepub.com)

The news correspondents report that additional information may be obtained from F. Deodato, Bambino Gesu Pediat Hosp, Dept. of Pediat Cardiol, IRCCS, I-00165 Rome, Italy. Additional authors for this research include V.M. Ginocchio, A. Onofri, G. Grutter, A. Germani and C. Dionisi-Vici (see also Nutritional and Metabolic Diseases and Conditions).

Keywords for this news article include: Rome, Italy, Europe, Antibodies, Blood Proteins, Enzymes and Coenzymes, Glucosidases, Glycogen Storage Disease, Glycoside Hydrolases, Immunoglobulins, Immunology, Nutritional and Metabolic Diseases and Conditions, Therapy

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


For more stories covering the world of technology, please see HispanicBusiness' Tech Channel



Source: Biotech Week


Story Tools






HispanicBusiness.com Facebook Linkedin Twitter RSS Feed Email Alerts & Newsletters