Study Data from A. Latorre and Colleagues Update Understanding of Nanoparticles (DNA and aptamer stabilized gold nanoparticles for targeted delivery of anticancer therapeutics)
The news correspondents obtained a quote from the research, "In this study, GNPs are loaded with doxorubicin or AZD8055, using a self-immolative linker which facilitates the release of anticancer therapeutics in malignant cells without modifications of the active compound. An additional modification with the aptamer AS1411 further increases the selectivity of GNPs towards cancer cells. Both modifications increase targeted delivery of therapeutics with GNPs. Whereas GNPs without anticancer drugs do not affect cell viability in all cells tested, AS1411 modified GNPs loaded with doxorubicin or AZD8055 show significant and increased reduction of cell viability in breast cancer and uveal melanoma cell lines."
According to the news reporters, the research concluded: "These results highlight that modified GNPs can be functionalized to increase the efficacy of cancer therapeutics and may further reduce toxicity by increasing targeted delivery towards malignant cells."
For more information on this research see: DNA and aptamer stabilized gold nanoparticles for targeted delivery of anticancer therapeutics. Nanoscale, 2014;6(13):7436-42. (
Our news journalists report that additional information may be obtained by contacting A. Latorre, Instituto Madrileno de Estudios Avanzados en Nanociencia, CNB-CSIC-IMDEA Nanociencia Associated Unit, Cantoblanco,
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Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC
OCTOBER 31, 2014
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