Studies from Tarbiat Modares University Describe New Findings in Cancer Gene Therapy (Bacteriophages and medical oncology: targeted gene therapy of cancer)
By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Current study results on Biotechnology have been published. According to news reporting originating in Tehran, Iran, by NewsRx journalists, research stated, "Targeted gene therapy of cancer is of paramount importance in medical oncology. Bacteriophages, viruses that specifically infect bacterial cells, offer a variety of potential applications in biomedicine."
The news reporters obtained a quote from the research from Tarbiat Modares University, "Their genetic flexibility to go under a variety of surface modifications serves as a basis for phage display methodology. These surface manipulations allow bacteriophages to be exploited for targeted delivery of therapeutic genes. Moreover, the excellent safety profile of these viruses paves the way for their potential use as cancer gene therapy platforms. The merge of phage display and combinatorial technology has led to the emergence of phage libraries turning phage display into a high throughput technology. Random peptide libraries, as one of the most frequently used phage libraries, provide a rich source of clinically useful peptide ligands. Peptides are known as a promising category of pharmaceutical agents in medical oncology that present advantages such as inexpensive synthesis, efficient tissue penetration and the lack of immunogenicity. Phage peptide libraries can be screened, through biopanning, against various targets including cancer cells and tissues that results in obtaining cancer-homing ligands. Cancer-specific peptides isolated from phage libraries show huge promise to be utilized for targeting of various gene therapy vectors towards malignant cells."
According to the news reporters, the research concluded: "Beyond doubt, bacteriophages will play a more impressive role in the future of medical oncology."
For more information on this research see: Bacteriophages and medical oncology: targeted gene therapy of cancer. Medical Oncology, 2014;31(8):204-214. Medical Oncology can be contacted at: Humana Press Inc, 999 Riverview Drive Suite 208, Totowa, NJ 07512, USA. (Springer - www.springer.com; Medical Oncology - www.springerlink.com/content/1357-0560/)
Our news correspondents report that additional information may be obtained by contacting B. Bakhshinejad, Tarbiat Modares Univ, Fac Biol Sci, Dept. of Genet, Tehran, Iran. Additional authors for this research include M. Karimi and M. Sadeghizadeh (see also Biotechnology).
Keywords for this news article include: Tehran, Iran, Asia, Bacteriophages, Bioengineering, Biotechnology, Cancer Gene Therapy, Genetics, Oncology, Peptides, Proteins, Proteomics, Technology, Viruses
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