Studies from School of Chemistry Yield New Data on Biosensing (Analysis of a convection-diffusion-reaction problem in a surface-based biosensor using the method of lines)
By a News Reporter-Staff News Editor at Biotech Week -- New research on Biosensing is the subject of a report. According to news reporting from Belem, Brazil, by NewsRx journalists, research stated, "The Method of Lines (MOL) was used to study the mass-transfer process and the underlying biomolecular interaction process on the surface based on biosensors, a new optical sensor technology of optical sensors that uses the surface plasmon resonance technique (SPR) to generate the extension of the kinetic process. A mathematical model was developed involving the convection-diffusion equation of mass transport coupled with an equation that describes the reversible chemical reaction between analyte and immobilized reactant."
The news correspondents obtained a quote from the research from the School of Chemistry, "A computer code in FORTRAN 90/95 programming language using the subroutine DIVPAG from the IMSL library was developed to numerically solve the system of ordinary differential equations resulting from the application of the MOL in the original model. The parameter values used for the simulation were chosen from the literature data to simulate typical cases. Therefore, the mathematical model proposed in this paper based on a problem of convection-diffusion-reaction was used to describe the biomolecular interactions process, and numerical results were generated to predict the time course for average free analyte concentration and average concentration of bound analyte-receptor complex to the phases of association and dissociation."
According to the news reporters, the research concluded: "These results were compared with those obtained with solution methodologies from other works in order to validate the mathematical model developed."
For more information on this research see: Analysis of a convection-diffusion-reaction problem in a surface-based biosensor using the method of lines. High Temperatures-High Pressures, 2014;43(5):369-384. High Temperatures-High Pressures can be contacted at: Old City Publishing Inc, 628 North 2ND St, Philadelphia, PA 19123, USA (see also Biosensing).
Our news journalists report that additional information may be obtained by contacting C.A.M. Silva, Inst Technol ITEC, Sch Chem Engn FEQ UFPA, Proc Simulat Lab LSP, Belem, Para, Brazil. Additional authors for this research include E.N. Macedo and J.N.N. Quaresma.
Keywords for this news article include: Belem, Brazil, South America, Bioengineering, Bionanotechnology, Biosensing, Biotechnology, Nanobiotechnology, Nanotechnology
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