Studies from Novartis Institute for Biomedical Research Add New Findings in the Area of Biomolecular Screening (Multiparametric Analysis of Screening Data: Growing Beyond the Single Dimension to Infinity and Beyond)
By a News Reporter-Staff News Editor at Biotech Week -- Investigators discuss new findings in Biotechnology. According to news reporting originating from Basel, Switzerland, by NewsRx correspondents, research stated, "Advances in instrumentation now allow the development of screening assays that are capable of monitoring multiple readouts such as transcript or protein levels, or even multiple parameters derived from images. Such advances in assay technologies highlight the complex nature of biology and disease."
Our news editors obtained a quote from the research from Novartis Institute for Biomedical Research, "Harnessing this complexity requires integration of all the different parameters that can be measured rather than just monitoring a single dimension as is commonly used. Although some of the methods used to combine multiple measurements, such as principal component analysis, are commonly used for microarray analysis, biologists are not yet using many of the tools that have been developed in other fields to address such issues. Visualization of multiparametric data sets is one of the major challenges in this field, and a depiction of the results in a manner that can be readily interpreted is essential. This article describes a number of assay systems being used to generate such data sets en masse, and the methods being applied to their visualization and analysis."
According to the news editors, the research concluded: "We also discuss some of the challenges of applying methods developed in other fields to biology."
For more information on this research see: Multiparametric Analysis of Screening Data: Growing Beyond the Single Dimension to Infinity and Beyond. Journal of Biomolecular Screening, 2014;19(5):628-639. Journal of Biomolecular Screening can be contacted at: Sage Publications Inc, 2455 Teller Rd, Thousand Oaks, CA 91320, USA. (Sage Publications - www.sagepub.com/; Journal of Biomolecular Screening - jbx.sagepub.com)
The news editors report that additional information may be obtained by contacting Y. Abraham, Novartis Inst Biomed Res, Basel, Switzerland. Additional authors for this research include X. Zhang and C.N. Parker (see also Biotechnology).
Keywords for this news article include: Basel, Switzerland, Europe, Biotechnology
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