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Studies from Chang Gung University Reveal New Findings on Tissue Engineering (Composite chitosan/silk fibroin nanofibers for modulation of osteogenic...

September 10, 2014



Studies from Chang Gung University Reveal New Findings on Tissue Engineering (Composite chitosan/silk fibroin nanofibers for modulation of osteogenic differentiation and proliferation of human mesenchymal stem cells)

By a News Reporter-Staff News Editor at Biotech Week -- Data detailed on Biomedicine and Biomedical Engineering have been presented. According to news originating from Taoyuan, Taiwan, by NewsRx correspondents, research stated, "Nanofibrous membrane scaffolds of chitosan (CS), silk fibroin (SF) and CS/SF blend were prepared by electrospinning and studied for growth and osteogenic differentiation of human bone marrow mesenchymal stem cells (hMSCs). The morphology and physico-chemical properties of all membrane scaffolds were compared."

Our news journalists obtained a quote from the research from Chang Gung University, "The influence of CS and SF on cell proliferation was assessed by the MTS assay, whereas osteogenic differentiation was determined from the Alizarin Red staining, alkaline phosphatase activity and expression of osteogenic marker genes. The osteogenic differentiation and proliferation of hMSCs were enhanced by CS and SF nanofibers, respectively. Blending CS with SF retained the osteogenesis nature of CS without negatively influencing the cell proliferative effect of SF."

According to the news editors, the research concluded: "By taking advantage of the differentiation/proliferation cues from individual components, the electrospun CS/SF composite nanofibrous membrane scaffold is suitable for bone tissue engineering."

For more information on this research see: Composite chitosan/silk fibroin nanofibers for modulation of osteogenic differentiation and proliferation of human mesenchymal stem cells. Carbohydrate Polymers, 2014;111():288-297. Carbohydrate Polymers can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Carbohydrate Polymers - www.elsevier.com/wps/product/cws_home/405871)

The news correspondents report that additional information may be obtained from G.J. Lai, Chang Gung Univ Sci & Technol, Res Center Ind Human Ecol, Taoyuan 333, Taiwan. Additional authors for this research include K.T. Shalumon, S.H. Chen and J.P. Chen (see also Biomedicine and Biomedical Engineering).

Keywords for this news article include: Taoyuan, Taiwan, Asia, Bioengineering, Biomedical Engineering, Biomedicine, Biomedicine and Biomedical Engineering, Bone Research, Emerging Technologies, Nanofiber, Nanotechnology, Tissue Engineering

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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