School of Chemistry and Biochemistry Reports Findings in Nanoparticles (Biological Targeting of Plasmonic Nanoparticles Improves Cellular Imaging via the Enhanced Scattering in the Aggregates Formed)
By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on Nanoparticles is now available. According to news reporting from Atlanta, Georgia, by NewsRx journalists, research stated, "Gold nanopartides (AuNPs) demonstrate great promise in biomedical applications due to their plasmonically enhanced imaging properties. When in close proximity, AuNPs plasmonic fields couple together, increasing their scattering cross-section due to the formation of hot spots, improving their imaging utility."
The news correspondents obtained a quote from the research from the School of Chemistry and Biochemistry, "In the present study, we modified the AuNPs surface with different peptides to target the nucleus and/or the cell as a whole, resulting in similar cellular uptake but different scattering intensities. Nuclear-targeted AuNPs showed the greatest scattering due to the formation of denser nanoparticle clusters (i.e., increased localization). We also obtained a dynamic profile of AuNP localization in living cells, indicating that nuclear localization is directly related to the number of nuclear-targeting peptides on the AuNP surface. Increased localization led to increased plasmonic field coupling, resulting in significantly higher scattering intensity."
According to the news reporters, the research concluded: "Thus, biochemical targeting of plasmonic nanoparticles to subcellular components is expected to lead to more resolved imaging of cellular processes."
For more information on this research see: Biological Targeting of Plasmonic Nanoparticles Improves Cellular Imaging via the Enhanced Scattering in the Aggregates Formed. Journal of Physical Chemistry Letters, 2014;5(15):2555-2561. Journal of Physical Chemistry Letters can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Journal of Physical Chemistry Letters - www.pubs.acs.org/journal/jpclcd)
Our news journalists report that additional information may be obtained by contacting M. Aioub, Georgia Inst Technol, Sch Chem & Biochem, Laser Dynam Lab, Atlanta, GA 30332, United States. Additional authors for this research include B. Kang, M.A. Mackey and M.A. El-Sayed (see also Nanoparticles).
Keywords for this news article include: Atlanta, Georgia, United States, North and Central America, Emerging Technologies, Nanoparticle, Nanoparticles, Nanotechnology
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