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Researchers from University of Santiago Report Details of New Studies and Findings in the Area of Supramolecular Research (Supramolecular gels of...

September 12, 2014



Researchers from University of Santiago Report Details of New Studies and Findings in the Area of Supramolecular Research (Supramolecular gels of poly-alpha-cyclodextrin and PEO-based copolymers for controlled drug release)

By a News Reporter-Staff News Editor at Drug Week -- Current study results on Supramolecular Research have been published. According to news reporting originating from Santiago de Compostela, Spain, by NewsRx correspondents, research stated, "The aim of this work was to prepare syringeable supramolecular gels of alpha-cyclodextrin-polymer (polyo-alpha CD) with various poly(ethylene oxide) (PEO)-based copolymers, which can be suitable to form depots for controlled drug release. A series of water-soluble poly-alpha CDs was synthesized from alpha CD by crosslinking with epichlorohydrin in alkaline medium."

Our news editors obtained a quote from the research from the University of Santiago, "The chemical composition of the polymers was characterized by NMR (alpha CD content > 53%) and the molecular weight was evaluated using static light scattering (SLS). Supramolecular assemblies occurred by mixing poly-alpha CD (20-40% w/v) with a PEO-based polymer (i.e., PEG, Pluronic ® F127 or Tetronic ® 908) (10-15% w/v). Phase separation was observed and the aCD content in each phase was determined by means of the phenol-sulfuric acid colorimetric method. Formation of poly-alpha CD/PEO-based polymer 3D-supramolecular complexes was confirmed by diffusion-ordered NMR spectroscopy (DOSY) and X-ray diffractometry. The supramolecular assemblies showed good cytocompatibility against SAOS-2 cells and in the HET-CAM test. The supramolecular gels were able to sustain the release of vancomycin for at least 5 days at 37 degrees C, more efficiently than dispersions of each polymer component in separate."

According to the news editors, the research concluded: "These results open new possibilities in the design of novel controlled delivery systems for the treatment of bone infections."

For more information on this research see: Supramolecular gels of poly-alpha-cyclodextrin and PEO-based copolymers for controlled drug release. European Journal of Pharmaceutics and Biopharmaceutics, 2014;87(3):579-588. European Journal of Pharmaceutics and Biopharmaceutics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; European Journal of Pharmaceutics and Biopharmaceutics - www.elsevier.com/wps/product/cws_home/600120)

The news editors report that additional information may be obtained by contacting S.M.N. Simoes, University of Santiago, Dept. of Fis Mat Condensada, Santiago De Compostela 15782, Spain. Additional authors for this research include F. Veiga, A.C.F. Ribeiro, A.R. Figueiras, P. Taboada, A. Concheiro and C. Alvarez-Lorenzo (see also Supramolecular Research).

Keywords for this news article include: Santiago de Compostela, Spain, Europe, Emerging Technologies, Nanotechnology, Supramolecular, Supramolecular Research

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Drug Week


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