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Researchers from University of Jinan Describe Findings in Neoplasm Antigens (Paper-based electrochemiluminescence immunodevice for carcinoembryonic...

September 9, 2014



Researchers from University of Jinan Describe Findings in Neoplasm Antigens (Paper-based electrochemiluminescence immunodevice for carcinoembryonic antigen using nanoporous gold-chitosan hybrids and graphene quantum dots functionalized Au@Pt)

By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Immunology. According to news reporting from Jinan, People's Republic of China, by NewsRx journalists, research stated, "A highly sensitive 3D origami device combined with electrochemiluminescence (ECL) immunosensor was introduced for sensitive point-of-care testing of carcinoembryonic antigen (CEA). This immunodevice was developed based on nanoporous gold/chitosan modified paper working electrode (NGC-PWE) as sensor platform and green-luminescent graphene quantum dots (GQDs) functionalized Au@Pt core-shell nanoparticles (GQDs/Au@Pt) as signal label."

The news correspondents obtained a quote from the research from the University of Jinan, "Firstly, the origami device was fabricated by directly screen-printing electrodes on wax-patterned pure cellulose paper. Secondly, the NGC hybrids were prepared and introduced for binding of primary antibody with high loading amount. The ECL nanoprobe (Ab(2)/GQD5/Au@Pt) was designed by covalent assembly of signal antibody (Ab(2)) on GQDs tagged Au@Pt core-shell nanoparticles. After a sandwich-type immunoreaction, the GQDs/Au@Pt labels were captured onto the NGC-PWE surface. The amplified ECL signals were achieved by efficient catalysis of the glucose oxidase (GOx) towards the oxidation of glucose to in situ generate H2O2 as coreactant and the enhancement of Au@Pt to the ECL reaction of GQDs-H2O2. Under the optimized experimental conditions, the proposed strategy exhibited excellent high sensitivity for the determination of CEA ranging from 1.0 pg mL(-1) to 10 ng mL(-1) with the detection limit of 0.6 pg mL(-1). The assay results of CEA in clinical serum samples were in a good agreement with the commercial ECL single-analyte tests."

According to the news reporters, the research concluded: "The proposed enhanced ECL immunosensor may become a promising technique for detection of other tumor markers."

For more information on this research see: Paper-based electrochemiluminescence immunodevice for carcinoembryonic antigen using nanoporous gold-chitosan hybrids and graphene quantum dots functionalized Au@Pt. Sensors and Actuators B-Chemical, 2014;202():314-322. Sensors and Actuators B-Chemical can be contacted at: Elsevier Science Sa, PO Box 564, 1001 Lausanne, Switzerland (see also Immunology).

Our news journalists report that additional information may be obtained by contacting L. Li, Univ Jinan, Shandong Prov Key Lab Preparat Measurement Bldg, Jinan 250022, People's Republic of China. Additional authors for this research include W.P. Li, C. Ma, H.M. Yang, S.G. Ge and J.H. Yu.

Keywords for this news article include: Jinan, People's Republic of China, Asia, Biological Tumor Markers, Carcinoembryonic Antigen, Cell Adhesion Molecules, Emerging Technologies, Glycoproteins, Immunology, Membrane Proteins, Nanoparticle, Nanoporous, Nanotechnology, Neoplasm Antigens, Quantum Dots, Quantum Physics

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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