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Researchers from Soochow University Report Findings in Silicon (Hairpin DNA-Assisted Silicon/Silver-Based Surface-Enhanced Raman Scattering Sensing...

September 9, 2014



Researchers from Soochow University Report Findings in Silicon (Hairpin DNA-Assisted Silicon/Silver-Based Surface-Enhanced Raman Scattering Sensing Platform for Ultrahighly Sensitive and Specific Discrimination of Deafness Mutations in a Real ...)

By a News Reporter-Staff News Editor at Life Science Weekly -- Research findings on Silicon are discussed in a new report. According to news reporting originating in Suzhou, People's Republic of China, by NewsRx journalists, research stated, "Surface-enhanced Raman scattering (SERS) is well-recognized as a powerful analytical tool for ultrahighly sensitive detection of analytes. In this article, we present a kind of silicon-based SERS sensing platform made of a hairpin DNA-modified silver nanoparticles decorated silicon wafer (AgNPs@Si)."

The news reporters obtained a quote from the research from Soochow University, "In particular, the AgNPs@Si with a high enhancement factor (EF) value of similar to 4.5 x 10(7) is first achieved under optimum reaction conditions (i.e., pH = 12, reaction time = 20 min) based on systematic investigation. Such resultant AgNPs@Si is then employed for construction of a silicon-based SERS sensing platform through surface modification of hairpin DNA, which is superbly suitable for highly reproducible, multiplexed, and ultrasensitive DNA detection. A detection limit of 1 fM is readily achieved in a very reproducible manner along with high specificity. Most significantly, for the first time, we demonstrate that the silicon-based SEAS platform is highly efficacious for discriminating deafness-causing mutations in a real system at the femtomolar level (500 fM), which is about 3-4 orders of magnitude lower than that (similar to 5 nM) ever reported by conventional detection methods."

According to the news reporters, the research concluded: "Our results raise the exciting potential of practical SEAS applications in biology and biomedicine."

For more information on this research see: Hairpin DNA-Assisted Silicon/Silver-Based Surface-Enhanced Raman Scattering Sensing Platform for Ultrahighly Sensitive and Specific Discrimination of Deafness Mutations in a Real System. Analytical Chemistry, 2014;86(15):7368-7376. Analytical Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Analytical Chemistry - www.pubs.acs.org/journal/ancham)

Our news correspondents report that additional information may be obtained by contacting H. Wang, Soochow Univ, Collaborat Innovat Center Hematol, Suzhou 215123, People's Republic of China. Additional authors for this research include X.X. Jiang, X. Wang, X.P. Wei, Y. Zhu, B. Sun, Y.Y. Su, S.D. He and Y. He (see also Silicon).

Keywords for this news article include: Suzhou, People's Republic of China, Asia, DNA Research, Silicon

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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