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Researchers from Madrid Polytechnic University Detail New Studies and Findings in the Area of Nanorods (Evaluation of Bioaccumulation Kinetics of...

September 12, 2014



Researchers from Madrid Polytechnic University Detail New Studies and Findings in the Area of Nanorods (Evaluation of Bioaccumulation Kinetics of Gold Nanorods in Vital Mammalian Organs by Means of Total Reflection X-Ray Fluorescence ...)

By a News Reporter-Staff News Editor at Health & Medicine Week -- A new study on Nanorods is now available. According to news reporting out of Madrid, Spain, by NewsRx editors, research stated, "This work presents the first application of total-reflection X-ray fluorescence (TXRF) spectrometry, a new and powerful alternative analytical method, to evaluation of the bioaccumulation kinetics of gold nanorods (GNRs) in various tissues upon intravenous administration in mice. The analytical parameters for developed methodology by TXRF were evaluated by means of the parallel analysis of bovine liver certified reference material samples (BCR-185R) doped with 10 mu g/g gold."

Our news journalists obtained a quote from the research from Madrid Polytechnic University, "The average values (n = 5) achieved for gold measurements in lyophilized tissue weight were as follows: recovery 99.7%, expanded uncertainty (k = 2) 7%, repeatability 1.7%, detection limit 112 ng/g, and quantification limit 370 ng/g. The GNR bioaccumulation kinetics was analyzed in several vital mammalian organs such as liver, spleen, brain, and lung at different times. Additionally, urine samples were analyzed to study the kinetics of elimination of the GNRs by this excretion route. The main achievement was clearly differentiating two kinds of behaviors. GNRs were quickly bioaccumulated by highly vascular filtration organs such as liver and spleen, while GNRs do not show a bioaccumulation rates in brain and lung for the period of time investigated. In parallel, urine also shows a lack of GNR accumulation."

According to the news editors, the research concluded: "TXRF has proven to be a powerful, versatile, and precise analytical technique for the evaluation of GNRs content in biological systems and, in a more general way, for any kind of metallic nanoparticles."

For more information on this research see: Evaluation of Bioaccumulation Kinetics of Gold Nanorods in Vital Mammalian Organs by Means of Total Reflection X-Ray Fluorescence Spectrometry. Analytical Chemistry, 2014;86(15):7383-7390. Analytical Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Analytical Chemistry - www.pubs.acs.org/journal/ancham)

Our news journalists report that additional information may be obtained by contacting R. Fernandez-Ruiz, Madrid Polytechnic University, Center Tecnol Biomed, Madrid 28223, Spain. Additional authors for this research include M.J. Redrejo, E.J. Friedrich, M. Ramos and T. Fernandez (see also Nanorods).

Keywords for this news article include: Madrid, Spain, Europe, Emerging Technologies, Nanorod, Nanorods, Nanotechnology

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Health & Medicine Week


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