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Researchers at National Institute on Alcohol Abuse and Alcoholism Have Reported New Data on Stem Cells (Pharmacological Mobilization of Endogenous...

September 10, 2014



Researchers at National Institute on Alcohol Abuse and Alcoholism Have Reported New Data on Stem Cells (Pharmacological Mobilization of Endogenous Stem Cells Significantly Promotes Skin Regeneration after Full-Thickness Excision: The ...)

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Stem Cell Research. According to news reporting out of Bethesda, Maryland, by NewsRx editors, research stated, "Stem cell therapy has shown promise in treating a variety of pathologies including skin wounds, but practical applications remain elusive. Here, we demonstrate that endogenous stem cell mobilization produced by AMD3100 and low-dose tacrolimus is able to reduce by 25% the time of complete healing of full-thickness wounds created by surgical excision."

Our news journalists obtained a quote from the research from National Institute on Alcohol Abuse and Alcoholism, "Equally important, healing was accompanied by reduced scar formation and regeneration of hair follicles. Searching for mechanisms, we found that AMD3100 combined with low-dose tacrolimus mobilized increased number of lineage-negative c-Kit+, CD34+, and CD133+ stem cells. Low-dose tacrolimus also increased the number of SDF-1-bearing macrophages in the wound sites amplifying the 'pull' of mobilized stem cells into the wound. Lineage tracing demonstrated the critical role of CD133 stem cells in enhanced capillary and hair follicle neogenesis, contributing to more rapid and perfect healing."

According to the news editors, the research concluded: "Our findings offer a significant therapeutic approach to wound healing and tissue regeneration."

For more information on this research see: Pharmacological Mobilization of Endogenous Stem Cells Significantly Promotes Skin Regeneration after Full-Thickness Excision: The Synergistic Activity of AMD3100 and Tacrolimus. Journal of Investigative Dermatology, 2014;134(9):2458-2468. Journal of Investigative Dermatology can be contacted at: Nature Publishing Group, 75 Varick St, 9TH Flr, New York, NY 10013-1917, USA. (Nature Publishing Group - www.nature.com/; Journal of Investigative Dermatology - www.nature.com/jid/)

Our news journalists report that additional information may be obtained by contacting Q. Lin, NIAAA, Lab Liver Dis, Bethesda, MD, United States. Additional authors for this research include R.N. Wesson, H. Maeda, Y.C. Wang, Z. Cui, J.O. Liu, A.M. Cameron, B. Gao, R.A. Montgomery, G.M. Williams and Z.L. Sun (see also Stem Cell Research).

Keywords for this news article include: Bethesda, Maryland, United States, North and Central America, Drugs, Immunosuppressive Agents, Macrolides, Pharmaceuticals, Pharmacology, Stem Cell Research, Tacrolimus, Therapy

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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