Researchers at Hoseo University Report New Data on Immune System (Zinc oxide nanoparticles, a novel candidate for the treatment of allergic inflammatory diseases)
By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators discuss new findings in Immune System. According to news reporting from Asan, South Korea, by NewsRx journalists, research stated, "Zinc (Zn) is an essential trace metal for eukaryotes. The roles of Zn in the numerous physiological functions have been elucidated."
The news correspondents obtained a quote from the research from Hoseo University, "Bamboo salt contains Zn that was shown to have anti-inflammatory effect and other health benefits. Nanoparticles of various types have found application in the biology, medicine, and physics. Here we synthesized tetrapod-like, zinc oxide nanoparticles (ZO-NP: diameter 200 nm, source of Zn) using a radio frequency thermal plasma system and investigated its effects on mast cell-mediated allergic inflammatory reactions. ZO-NP was found to inhibit the productions and mRNA expressions of inflammatory cytokines such as interleukin (IL)-1 beta, IL-6, and tumor necrosis factor-alpha on the phorbol 12-myristate 13-acetate plus A23187 (PMACI)-stimulated human mast cell line, HMC-1 cells. In these stimulated cells, caspase-1 and nuclear factor-kappa B activations were abolished by ZO-NP, and the expressions of receptor interacting protein2 (RIP2) and I kappa B kinase beta (IKK beta) induced by PAMCI were reduced. On the other hand, ZO-NP alone increased the expressions of RIP2 and IKK beta in normal condition. ZO-NP inhibited the phosphorylation of extracellular signal-regulated protein kinase in the PMACI-stimulated HMC-1 cells. Furthermore, ZO-NP significantly inhibited passive cutaneous anaphylaxis activated by anti-dinitrophenyl IgE."
According to the news reporters, the research concluded: "These findings indicate that ZO-NP effectively ameliorates mast cell mediated allergic inflammatory reaction, and suggest that ZO-NP be considered a potential therapeutic for the treatment of mast cell mediated allergic diseases."
For more information on this research see: Zinc oxide nanoparticles, a novel candidate for the treatment of allergic inflammatory diseases. European Journal of Pharmacology, 2014;738():31-39. European Journal of Pharmacology can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; European Journal of Pharmacology - www.elsevier.com/wps/product/cws_home/506087)
Our news journalists report that additional information may be obtained by contacting M.H. Kim, Hoseo Univ, Inflammatory Dis Res Center, Asan, South Korea. Additional authors for this research include J.H. Seo, H.M. Kim and H.J. Jeong (see also Immune System).
Keywords for this news article include: Asan, South Korea, Asia, Emerging Technologies, Enzymes and Coenzymes, Immune System, Kinase, Mast Cells, Nanoparticle, Nanotechnology
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