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Research Conducted at Rensselaer Polytechnic Institute Has Provided New Information about Nanoparticles (Nanoparticle enabled drug delivery across...

September 10, 2014



Research Conducted at Rensselaer Polytechnic Institute Has Provided New Information about Nanoparticles (Nanoparticle enabled drug delivery across the blood brain barrier: in vivo and in vitro models, opportunities and challenges)

By a News Reporter-Staff News Editor at Biotech Week -- Researchers detail new data in Nanoparticles. According to news reporting out of Troy, New York, by NewsRx editors, research stated, "The blood brain barrier (BBB) maintains homeostasis by regulating the transport of chemicals at the brain interface. However, it is also one of the largest obstacles for drug delivery to the central nervous system (CNS)."

Our news journalists obtained a quote from the research from Rensselaer Polytechnic Institute, "The utilization of nanoparticles as drug delivery vehicles is one potential solution to overcome this barrier. This review highlights the characteristics of the BBB that inhibit the passage of drugs to the brain, evaluates the efficiency of current in vitro models to mimic the BBB, and discusses the use of nanoparticles in both in vivo and in vitro models to enhance drug permeability across the barrier. In addition, this review describes factors that influence the passage of nanoparticles (type of polymers and surfactant coating, nanoparticle size) across the barrier. Protein opsonization and phagocytic activity of the reticuloendothelial system limits the amount of drug delivered to the brain, and this article summarizes methods to circumvent these issues."

According to the news editors, the research concluded: "This paper also reviews literature covering opportunities and challenges provided with current applications of nanoparticle drug delivery systems for diseases of the brain, including cancer, HIV, and Alzheimer's disease."

For more information on this research see: Nanoparticle enabled drug delivery across the blood brain barrier: in vivo and in vitro models, opportunities and challenges. Current Pharmaceutical Biotechnology, 2014;14(14):1201-12. (Bentham Science Publishers - www.benthamscience.com; Current Pharmaceutical Biotechnology - www.benthamscience.com/cpb/index.htm)

Our news journalists report that additional information may be obtained by contacting M. Gidwani, Dept. of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, United States (see also Nanoparticles).

Keywords for this news article include: Troy, New York, United States, North and Central America, Emerging Technologies, Nanoparticle, Nanoparticles, Nanotechnology.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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