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Reports from University of Ottawa Provide New Insights into Phenothiazines (Metal-Free Photocatalytic Radical Trifluoromethylation Utilizing...

September 10, 2014



Reports from University of Ottawa Provide New Insights into Phenothiazines (Metal-Free Photocatalytic Radical Trifluoromethylation Utilizing Methylene Blue and Visible Light Irradiation)

By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Phenothiazines have been published. According to news reporting out of Ottawa, Canada, by NewsRx editors, research stated, "The use of organofluorine compounds, especially those with an incorporated trifluoromethyl moiety, has increased dramatically in both the pharmaceutical and agrochemical industry. It has therefore become imperative to develop a mild and efficient synthetic technique for the inclusion of trifluoromethyl groups."

Our news journalists obtained a quote from the research from the University of Ottawa, "Herein, we report the first use of methylene blue as a photosensitizer for the catalytic radical trifluoro- and hydrotrifluoromethylation of electron-rich heterocycles as well as terminal alkenes and alkynes under visible light irradiation. These reactions proceed with moderate to good yields at low catalyst concentrations; short irradiation times; and most importantly, without the need for potentially toxic transition-metal catalysts."

According to the news editors, the research concluded: "In this work, considerable emphasis was also placed on understanding the kinetics of the mechanistically key steps through the use of laser flash photolysis techniques to more efficiently optimize the reaction conditions."

For more information on this research see: Metal-Free Photocatalytic Radical Trifluoromethylation Utilizing Methylene Blue and Visible Light Irradiation. ACS Catalysis, 2014;4(8):2530-2535. ACS Catalysis can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Catalysis - www.pubs.acs.org/journal/accacs)

Our news journalists report that additional information may be obtained by contacting S.P. Pitre, University of Ottawa, Center Catalysis Res & Innovat, Ottawa, ON K1N 6N5, Canada. Additional authors for this research include C.D. McTiernan, H. Ismaili and J.C. Scaiano (see also Phenothiazines).

Keywords for this news article include: Ottawa, Ontario, Canada, North and Central America, Antidotes, Drugs, Emerging Technologies, Methylene Blue, Nanotechnology, Phenothiazines, Photocatalyst, Photocatalytic, Therapy, Urinary Antiinfectives

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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