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Reports from University Health Network Add New Data to Findings in Drug Resistance (Carboxymethylcellulose-Based and Docetaxel-Loaded Nanoparticles...

September 10, 2014



Reports from University Health Network Add New Data to Findings in Drug Resistance (Carboxymethylcellulose-Based and Docetaxel-Loaded Nanoparticles Circumvent P-Glycoprotein-Mediated Multidrug Resistance)

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Drugs and Therapies. According to news reporting from Toronto, Canada, by NewsRx journalists, research stated, "Taxanes are a class of anticancer agents with a broad spectrum and have been widely used to treat a variety of cancer. However, its long-term use has been hampered by accumulating toxicity and development of drug resistance."

The news correspondents obtained a quote from the research from University Health Network, "The most extensively reported mechanism of resistance is the overexpression of P-glycoprotein (Pgp). We have developed a PEGylated carboxymethylcellulose conjugate of docetaxel (Cellax), which condenses into similar to 120 nm nanoparticles. Here we demonstrated that Cellax therapy did not upregulate Pgp expression in MDA-MB-231 and EMT-6 breast tumor cells, whereas a significant increase in Pgp expression was measured with native docetaxel (DTX) treatment. Treatment with DTX led to 4-7-fold higher Pgp mRNA expression and 2-fold higher Pgp protein expression compared with Cellax treatment in the in vitro and in vivo system, respectively. Cellax also exhibited significantly increased efficacy compared with that of DTX in a taxane-resistant breast tumor model."

According to the news reporters, the research concluded: "Against the highly Pgp expressing EMT6/AR1 cells, Cellax exhibited a 6.5 times lower IC50 compared with that of native DTX, and in the in vivo model, Cellax exhibited 90% tumor growth inhibition, while native DTX had no significant antitumor activity."

For more information on this research see: Carboxymethylcellulose-Based and Docetaxel-Loaded Nanoparticles Circumvent P-Glycoprotein-Mediated Multidrug Resistance. Molecular Pharmaceutics, 2014;11(8):2592-2599. Molecular Pharmaceutics can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Molecular Pharmaceutics - www.pubs.acs.org/journal/mpohbp)

Our news journalists report that additional information may be obtained by contacting A. Roy, Univ Hlth Network, Techna Inst, Toronto, ON M5G 1PS, Canada. Additional authors for this research include M. Murakami, M.J. Ernsting, B. Hoang, E. Undzys and S.D. Li (see also Drugs and Therapies).

Keywords for this news article include: Toronto, Ontario, Canada, North and Central America, ATP-Binding Cassette Transporters, ATP-Dependent Organic Anion Transporters, Anion Transport Proteins, Antineoplastics, Carrier Proteins, Docetaxel, Drug Resistance, Drugs, Drugs and Therapies, Emerging Technologies, Glycoconjugates, Ion Pumps, Membrane Glycoproteins, Membrane Proteins, Membrane Transport Proteins, Mitotic Inhibitors, Nanoparticle, Nanotechnology, P-Glycoproteins, Pharmaceuticals, Therapy

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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