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Reports from Nanjing University Describe Recent Advances in Biosensing (Multivalent Capture and Detection of Cancer Cells with DNA Nanostructured...

September 9, 2014



Reports from Nanjing University Describe Recent Advances in Biosensing (Multivalent Capture and Detection of Cancer Cells with DNA Nanostructured Biosensors and Multibranched Hybridization Chain Reaction Amplification)

By a News Reporter-Staff News Editor at Cancer Weekly -- Investigators publish new report on Biosensing. According to news reporting from Jiangsu, People's Republic of China, by NewsRx journalists, research stated, "Sensitive detection of cancer cells plays a critically important role in the early detection of cancer and cancer metastasis. However, because circulating tumor cells are extremely rare in peripheral blood, the detection of cancer cells with high analytical sensitivity and specificity remains challenging."

The news correspondents obtained a quote from the research from Nanjing University, "Here, we have demonstrated a simple, sensitive and specific detection of cancer cells with the detection sensitivity of four cancer cells, which is lower than the cutoff value with respect to correlation with survival outcomes as well as predictive of metastatic disease in clinical diagnostics. We re-engineered the hybridization chain reaction (HCR) to multibranched HCR (mHCR) that can produce long products with multiple biotins for signal amplification and multiple branched arms for multivalent binding. The capturing gold surface is modified with DNA tetrahedral probes, which provide superior hybridization conditions for the multivalent binding."

According to the news reporters, the research concluded: "The synergetic effect of mHCR amplification and multivalent binding lead to the high sensitivity of our detection platform."

For more information on this research see: Multivalent Capture and Detection of Cancer Cells with DNA Nanostructured Biosensors and Multibranched Hybridization Chain Reaction Amplification. Analytical Chemistry, 2014;86(15):7843-7848. Analytical Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Analytical Chemistry - www.pubs.acs.org/journal/ancham)

Our news journalists report that additional information may be obtained by contacting G.B. Zhou, Nanjing Univ Posts & Telecommun, IAM, Nanjing 210046, Jiangsu, People's Republic of China. Additional authors for this research include M.H. Lin, P. Song, X.Q. Chen, J. Chao, L.H. Wang, Q. Huang, W. Huang, C.H. Fan and X.L. Zuo (see also Biosensing).

Keywords for this news article include: Jiangsu, People's Republic of China, Asia, Bioengineering, Bionanotechnology, Biosensing, Biotechnology, Cancer, Nanobiotechnology, Nanotechnology, Oncology

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Weekly


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