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Reports from Faculty of Pharmacy Describe Recent Advances in Dexamethasone Therapy (pH-Sensitive Cationic Copolymers of Different Macromolecular...

September 10, 2014



Reports from Faculty of Pharmacy Describe Recent Advances in Dexamethasone Therapy (pH-Sensitive Cationic Copolymers of Different Macromolecular Architecture as Potential Dexamethasone Sodium Phosphate Delivery Systems)

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Drugs and Therapies. According to news reporting out of Sofia, Bulgaria, by NewsRx editors, research stated, "This paper describes the synthesis and characterization of cationic copolymers with different macromolecular architecture and drug delivery properties of the corresponding dexamethasone sodium phosphate (DSP)-loaded systems. Copolyelectrolytes comprising poly[2-(acryloyloxy)ethyl] trimethylammonium chloride (PAETMAC) and poly(ethylene glycol) blocks as well as a tri-arm star-shaped PAETMAC were synthesized using cerium(IV) ion-mediated polymerization method."

Our news journalists obtained a quote from the research from the Faculty of Pharmacy, "The obtained copolyelectrolytes and corresponding ionic associates with DSP have been characterized by H-1 NMR, Fourier Transform Infrared spectroscopy, and differential scanning calorimetry. The average diameter, size distribution, and -potential of the copolymers and DSP-copolymer ionic associates were determined by dynamic light scattering, and particles were visualized by scanning electron microscopy and transmission electron microscopy. The biocompatibility and cytotoxicity of obtained copolymers were determined."

According to the news editors, the research concluded: "In vitro drug release experiments were carried out to estimate the ability of the obtained nanoparticles for sustained release of DSP for a period of 24 h."

For more information on this research see: pH-Sensitive Cationic Copolymers of Different Macromolecular Architecture as Potential Dexamethasone Sodium Phosphate Delivery Systems. Journal of Pharmaceutical Sciences, 2014;103(8):2406-2413. Journal of Pharmaceutical Sciences can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Journal of Pharmaceutical Sciences - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1520-6017)

Our news journalists report that additional information may be obtained by contacting D. Georgieva, Medical Univ Sofia, Fac Pharm, Dept. of Pharmacol Pharmacotherapy & Toxicol, Sofia 1000, Bulgaria. Additional authors for this research include B. Kostova, S. Ivanova, D. Rachev, V. Tzankova, M. Kondeva-Burdina and D. Christova (see also Drugs and Therapies).

Keywords for this news article include: Sofia, Bulgaria, Europe, Adrenal Cortical Steroids, Anions, Chemicals, Chemistry, Dexamethasone, Drugs, Drugs and Therapies, Glucocorticoids, Hormones, Ophthalmic Preparations, Ophthalmic Steroids, Pharmaceuticals, Phosphates, Phosphoric Acids, Sodium Phosphate, Therapy, Topical Agents

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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