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Reports from A. Mattesini and Co-Researchers Add New Data to Findings in Cardiology (ABSORB Biodegradable Stents Versus Second-Generation Metal...

September 8, 2014

Reports from A. Mattesini and Co-Researchers Add New Data to Findings in Cardiology (ABSORB Biodegradable Stents Versus Second-Generation Metal Stents)

By a News Reporter-Staff News Editor at Cardiovascular Week -- Investigators publish new report on Cardiology. According to news reporting from Milan, Italy, by NewsRx journalists, research stated, "The aim of this study was to compare the acute performance of the PLLA ABSORB bioresorbable vascular scaffold (BVS) (Abbott Vascular, Santa Clara, California) with second-generation metal drug-eluting stents (DES) in complex coronary artery lesions. Thick polymer-based BVS have different mechanical properties than thin second-generation DES."

The news correspondents obtained a quote from the research, "Data on the acute performance of BVS are limited to simple coronary lesions treated in trials with strict inclusion criteria. Fifty complex coronary lesions (all type American College of Cardiology/American Heart Association B2-C) treated with a BVS undergoing a final optical coherence tomography (OCT) examination were compared with an equal number of matched lesions treated with second-generation DES. The following stent performance indexes were assessed with OCT: mean and minimal area, residual area stenosis (RAS), incomplete strut apposition (ISA), tissue prolapse, eccentricity index, symmetry index, strut fracture, and edge dissection. One hundred lesions from 73 patients were analyzed. A higher balloon diameter/reference vessel diameter ratio was used for predilation in the BVS group (p < 0.01). Most of the BVS and DES were post-dilated with short noncompliant (NC) balloons of similar diameter. OCT showed in the BVS group a higher tissue prolapse area (p = 0.08) and greater incidence of ISA at the proximal edge (p = 0.04) with no difference in the overall ISA. The RAS was 20.2% in the BVS group and 21.7% in the DES group (p = 0.32). There was no difference in the eccentricity index. The minimal and mean lumen areas were similar in the 2 groups. Two cases of strut fractures occurred after the BVS, whereas none was observed in the DES. Based on OCT, the BVS showed similar post-procedure area stenosis, minimal lumen area, and eccentricity index as second-generation DES."

According to the news reporters, the research concluded: "The different approach for lesion preparation and routine use of OCT guidance during BVS expansion may have contributed to these results."

For more information on this research see: ABSORB Biodegradable Stents Versus Second-Generation Metal Stents. Jacc-Cardiovascular Interventions, 2014;7(7):741-750. Jacc-Cardiovascular Interventions can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA (see also Cardiology).

Our news journalists report that additional information may be obtained by contacting A. Mattesini, EMO GVM Center Cuore Columbus, Intervent Cardiol Unit, Milan, Italy. Additional authors for this research include G.G. Secco, G. Dall'Ara, M. Ghione, J.C. Rama-Merchan, A. Lupi, N. Viceconte, A.C. Lindsay, R. De Silva, N. Foin, T. Naganuma, S. Valente, A. Colombo and C. Di Mario.

Keywords for this news article include: Milan, Italy, Europe, Angiology, Cardiology, Stenosis

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Source: Cardiovascular Week

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