Recent Findings in Physical Chemistry Described by Researchers from Stockholm University (Next-Generation Epigenetic Detection Technique: Identifying Methylated Cytosine Using Graphene Nanopore)
By a News Reporter-Staff News Editor at Life Science Weekly -- Fresh data on Physical Chemistry are presented in a new report. According to news reporting from Stockholm, Sweden, by NewsRx journalists, research stated, "DNA methylation plays a pivotal role in the genetic evolution of both embryonic and adult cells. For adult somatic cells, the location and dynamics of methylation have been very precisely pinned down with the 5-cytosine markers on cytosine-phosphate-guanine (CpG) units."
The news correspondents obtained a quote from the research from Stockholm University, "Unusual methylation on CpG islands is identified as one of the prime causes for silencing the tumor suppressant genes. Early detection of methylation changes can diagnose the potentially harmful oncogenic evolution of cells and provide promising guideline for cancer prevention. With this motivation, we propose a cytosine methylation detection technique. Our hypothesis is that electronic signatures of DNA acquired as a molecule translocates through a nanopore would be significantly different for methylated and nonmethylated bases. This difference in electronic fingerprints would allow for reliable real-time differentiation of methylated DNA. We calculate transport currents through a punctured graphene membrane while the cytosine and methylated cytosine translocate through the nanopore. We also calculate the transport properties for uracil and cyanocytosine for comparison. Our calculations of transmission, current, and tunneling conductance show distinct signatures in their spectrum for each molecular type."
According to the news reporters, the research concluded: "Thus, in this work, we provide a theoretical analysis that points to a viability of our hypothesis."
For more information on this research see: Next-Generation Epigenetic Detection Technique: Identifying Methylated Cytosine Using Graphene Nanopore. Journal of Physical Chemistry Letters, 2014;5(15):2601-2607. Journal of Physical Chemistry Letters can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Journal of Physical Chemistry Letters - www.pubs.acs.org/journal/jpclcd)
Our news journalists report that additional information may be obtained by contacting T. Ahmed, Stockholm University, S-10691 Stockholm, Sweden. Additional authors for this research include J.T. Haraldsen, J.X. Zhu and A.V. Balatsky (see also Physical Chemistry).
Keywords for this news article include: Stockholm, Sweden, Europe, Genetics, Physical Chemistry
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