New Stroke Findings from
Our news editors obtained a quote from the research, "In this study, combination of r-tPA and APT102, a novel form of human apyrase/ADPase, was investigated in a clinically-relevant aged-female rat embolic ischemic stroke model. We propose that successfully extending the therapeutic window of r-tPA administration would represent a significant advance in the treatment of ischemic stroke clue to a significant increase in the number of patients eligible for treatment. Results of our study showed significantly reduced mortality from 47% with r-tPA alone to 16% with co-administration of APT102 and r-tPA. Co-administration decreased cortical (47 5% vs. 29 5%), striatal (50 +/- 2%, vs. 40 +/- 3%) and total (48 +/- 3%vs. 33 +/- 4%) hemispheric infarct volume compared to r-tPA alone. APT102 improved neurological outcome (8.9 +/- 0.6, vs. 6.8 0.8) and decreased hemoglobin extravasation in cortical tissue (1.9 +/- 0.1 mg/dl vs. 14 +/- 0.1 mg/dl) striatal tissue (2.1 +/- 0.3 mg/dl vs. 1.4 +/- 0.1 mg/dl) and whole brain tissue (2.0 +/- 0.2 mg/dl vs. 1.4 +/- 0.1 mg/dl). These data suggest that APT102 can safely extend the therapeutic window for r-tPA mediated reperfusion to 6 h following experimental stroke without increased hemorrhagic transformation."
According to the news editors, the research concluded: "APT102 offers to be a viable adjunct therapeutic option to increase the number of clinical patients eligible for thrombolytic treatment after ischemic stroke."
For more information on this research see: Combination treatment of r-tPA and an optimized human apyrase reduces mortality rate and hemorrhagic transformation 6 h after ischemic stroke in aged female rats.
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