New Stem Cells Findings from University of Nebraska Reported (Electrospun ultrafine fibrous wheat glutenin scaffolds with three-dimensionally random organization and water stability for soft tissue engineering)
By a News Reporter-Staff News Editor at Biotech Week -- Fresh data on Stem Cell Research are presented in a new report. According to news reporting from Lincoln, Nebraska, by NewsRx journalists, research stated, "Wheat glutenin, the highly crosslinked protein from wheat, was electrospun into scaffolds with ultrafine fibers oriented randomly and evenly in three dimensions to simulate native extracellular matrices of soft tissues. The scaffolds were intrinsically water-stable without using any external crosslinkers and could support proliferation and differentiation of adipose-derived mesenchymal stem cells for soft tissue engineering."
The news correspondents obtained a quote from the research from the University of Nebraska, "Regeneration of soft tissue favored water-stable fibrous protein scaffolds with three-dimensional arrangement and large volumes, which could be difficult to obtain via electrospinning. Wheat glutenin is an intrinsically water-stable protein due to the 2% cysteine in its amino acid composition. In this research, the disulfide crosslinks in wheat glutenin were cleaved while the backbones were preserved. The treated wheat glutenin was dissolved in aqueous solvent with an anionic surfactant and then electrospun into bulky scaffolds composed of ultrafine fibers oriented randomly in three dimensions. The scaffolds could maintain their fibrous structures after incubated in PBS for up to 35 days."
According to the news reporters, the research concluded: "In vitro study indicated that the three-dimensional wheat glutenin scaffolds well supported uniform distribution and adipogenic differentiation of adipose derived mesenchymal stem cells."
For more information on this research see: Electrospun ultrafine fibrous wheat glutenin scaffolds with three-dimensionally random organization and water stability for soft tissue engineering. Journal of Biotechnology, 2014;184():179-186. Journal of Biotechnology can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Biotechnology - www.elsevier.com/wps/product/cws_home/505515)
Our news journalists report that additional information may be obtained by contacting H.L. Xu, University of Nebraska, Nebraska Center Mat & Nanosci, Lincoln, NE 68583, United States. Additional authors for this research include S.B. Cai, A. Sellers and Y.Q. Yang (see also Stem Cell Research).
Keywords for this news article include: Lincoln, Nebraska, United States, North and Central America, Bioengineering, Biomedical Engineering, Biomedicine, Mesenchymal Stem Cells, Stem Cell Research, Tissue Engineering
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