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New Porous Silicon Findings from University of Turku Described (In Vivo Evaluation of Porous Silicon and Porous Silicon Solid Lipid Nanocomposites...

September 9, 2014



New Porous Silicon Findings from University of Turku Described (In Vivo Evaluation of Porous Silicon and Porous Silicon Solid Lipid Nanocomposites for Passive Targeting and Imaging)

By a News Reporter-Staff News Editor at Cancer Weekly -- A new study on Porous Silicon is now available. According to news reporting originating in Turku, Finland, by NewsRx journalists, research stated, "The use of nanoparticle carriers for the sustained release of cytotoxic drugs in cancer therapy can result in fewer adverse effects and can thus be of great benefit for the patient. Recently, a novel nanocomposite, prepared by the encapsulation of THCPSi nanoparticles within solid lipids (SLN), was developed and characterized as a promising drug delivery carrier in vitro."

The news reporters obtained a quote from the research from the University of Turku, "The present study describes the in vivo evaluation of unmodified THCPSi nanopartides and THCPSi solid lipid nanocomposites (THCPSi-SLNCs) as potential drug delivery carriers for cancer therapy by using F-18 radiolabeling for the detection of the particle biodistribution in mice. Passive tumor targeting of F-18-THCPSis and F-18-THCPSi-SLNCs by the enhanced permeation and retention effect was investigated in a murine breast cancer model."

According to the news reporters, the research concluded: "Encapsulation of THCPSi nanoparticles with solid lipids improved their accumulation in tumors at a 7 week time point (tumor-to-liver ratio 0.10 +/- 0.08 and 0.24 +/- 0.0996 for F-18-THCPSis and F-18-THCPSi SLNCs, respectively)."

For more information on this research see: In Vivo Evaluation of Porous Silicon and Porous Silicon Solid Lipid Nanocomposites for Passive Targeting and Imaging. Molecular Pharmaceutics, 2014;11(8):2876-2886. Molecular Pharmaceutics can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Molecular Pharmaceutics - www.pubs.acs.org/journal/mpohbp)

Our news correspondents report that additional information may be obtained by contacting A.M. Kallinen, University of Turku, Dept. of Phys & Astron, Lab Ind Phys, FI-20014 Turku, Finland. Additional authors for this research include M.P. Sarparanta, D.F. Liu, E.M. Makila, J.J. Salonen, J.T. Hirvonen, H.A. Santos and A.J. Airaksinen (see also Porous Silicon).

Keywords for this news article include: Turku, Finland, Europe, Cancer, Emerging Technologies, Nanoparticle, Nanotechnology, Oncology, Porous Silicon

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Weekly


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