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New Intercellular Signaling Peptides and Proteins Study Findings Have Been Reported by Investigators at National Taiwan University (Sensitive...

September 9, 2014



New Intercellular Signaling Peptides and Proteins Study Findings Have Been Reported by Investigators at National Taiwan University (Sensitive Detection of Platelet-Derived Growth Factor through Surface-Enhanced Raman Scattering)

By a News Reporter-Staff News Editor at Life Science Weekly -- Fresh data on Intercellular Signaling Peptides and Proteins are presented in a new report. According to news originating from Taipei, Taiwan, by NewsRx correspondents, research stated, "A surface-enhanced Raman scattering (SERS) assay using two different nanomaterials has been demonstrated for highly sensitive and selective detection of platelet-derived growth factor (PDGF). Gold nanoparticles (Au NPs; 13 nm) are conjugated with aptamer (Apt) and 4-mercaptobenzoic acid while Au pearl necklace nanomaterials (Au PNNs) are used for (MBA) as the recognition element and reporter, respectively, generating reproducible and enhanced SERS signal of 4-MBA."

Our news journalists obtained a quote from the research from National Taiwan University, "The Apt/MBA-Au NPs bind PDGF through a specific interaction between Apt and PDGF in a fashion of 2:1, leading to concentration of the analyte and removal of the sample matrix. Through electrostatic interaction, the PDGF-Apt/MBA-Au NPs complexes form aggregates with Au PNNs, leading to an enhanced Raman signal of 4-MBA. Au PNNs allow enhancement factors up to 1.3 x 10(7) and relative standard deviations of Raman signals for 4-MBA down to 15% (five measurements). The assay allows detection of PDGF BB down to 0.5 pM, with linearity of the Raman signal of 4-MBA against the concentration of PDGF over 1-50 pM."

According to the news editors, the research concluded: "Having advantages of sensitivity and reproducibility, this assay has been further applied for the determination of the concentration of PDGF in urine samples, showing its great potential for ultrasensitive analysis of target proteins in biological samples."

For more information on this research see: Sensitive Detection of Platelet-Derived Growth Factor through Surface-Enhanced Raman Scattering. Analytical Chemistry, 2014;86(15):7606-7611. Analytical Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Analytical Chemistry - www.pubs.acs.org/journal/ancham)

The news correspondents report that additional information may be obtained from C.W. Wang, National Taiwan University, Dept. of Chem, Taipei 10617, Taiwan (see also Intercellular Signaling Peptides and Proteins).

Keywords for this news article include: Taipei, Taiwan, Asia, Blood Proteins, Emerging Technologies, Intercellular Signaling Peptides and Proteins, Nanomaterial, Nanotechnology, Platelet-Derived Growth Factor

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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