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New Gliomas Study Findings Have Been Reported by Investigators at Fudan University (Angiopep-2 and Activatable Cell-Penetrating Peptide...

September 10, 2014



New Gliomas Study Findings Have Been Reported by Investigators at Fudan University (Angiopep-2 and Activatable Cell-Penetrating Peptide Dual-Functionalized Nanoparticles for Systemic Glioma-Targeting Delivery)

By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Oncology have been published. According to news reporting originating in Shanghai, People's Republic of China, by NewsRx journalists, research stated, "Gliomas are hard to treat because of the two barriers involved: the blood brain barrier and blood tumor barrier. In this study, a dual-targeting ligand, angiopep-2, and an activatable cell-penetrating peptide (ACP) were functionalized onto nanoparticles for glioma-targeting delivery."

The news reporters obtained a quote from the research from Fudan University, "The ACP was constructed by conjugating RRRRRRRR (R8) with EEEEEEEE through a matrix metalloproteinase-2 (MMP-2)-sensitive linker. ACP modification effectively enhanced the C6 cellular uptake because of the high expression of MMP-2 on C6 cells. The uptake was inhibited by batimastat, an MMP-2 inhibitor, suggesting that the cell-penetrating property of the ACP was activated by MMIP-2. By combining the dual-targeting delivery effect of angiopep-2 and activatable cell-penetrating property of the ACP, the dual-modified nanoparticles (AnACNPs) displayed higher glioma localization than that of single ligand-modified nanoparticles. After loading with docetaxel, a common chemotherapeutic, AnACNPs showed the most favorable antiglioma effect both in vitro and in vivo."

According to the news reporters, the research concluded: "A novel drug delivery system was developed for glioma dual targeting and glioma penetrating. The results demonstrated that the system effectively targeted gliomas and provided the most favorable antiglioma effect."

For more information on this research see: Angiopep-2 and Activatable Cell-Penetrating Peptide Dual-Functionalized Nanoparticles for Systemic Glioma-Targeting Delivery. Molecular Pharmaceutics, 2014;11(8):2755-2763. Molecular Pharmaceutics can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Molecular Pharmaceutics - www.pubs.acs.org/journal/mpohbp)

Our news correspondents report that additional information may be obtained by contacting H.L. Gao, Fudan University, Key Lab Smart Drug Delivery, Minist Educ, Dept. of PharmaceutSci Sch Pharm, Shanghai 201203, People's Republic of China. Additional authors for this research include S. Zhang, S.J. Cao, Z. Yang, Z.Q. Pang and X.G. Jiang (see also Oncology).

Keywords for this news article include: Shanghai, People's Republic of China, Asia, Emerging Technologies, Glioma, Nanoparticle, Nanotechnology, Oncology

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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