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New Findings Reported from Fudan University Describe Advances in Magnetic Nanoparticles (Highly Selective and Ultra Fast Solid-Phase Extraction of...

September 9, 2014



New Findings Reported from Fudan University Describe Advances in Magnetic Nanoparticles (Highly Selective and Ultra Fast Solid-Phase Extraction of N-Glycoproteome by Oxime Click Chemistry Using Aminooxy-Functionalized Magnetic Nanoparticles)

By a News Reporter-Staff News Editor at Life Science Weekly -- Data detailed on Magnetic Nanoparticles have been presented. According to news originating from Shanghai, People's Republic of China, by NewsRx correspondents, research stated, "For the highly efficient extraction of the N-glycoproteome, a novel solid-phase extraction method based on oxime click chemistry has been developed."

Our news journalists obtained a quote from the research from Fudan University, "With the use of a newly synthesized aminooxy-functionalized magnetic nanoparticle, the oxidized glycan chains on glycopeptides readily react with the aminooxy groups through mime click chemistry, resulting in the highly selective extraction of glycopeptides. Compared to the traditional hydrazide chemistry-based method, which takes 12-16 h of coupling time, this new method renders excellent enrichment performance within 1 h. Furthermore, the enrichment sensitivity (fmol level), selectivity (extracting glycopeptides from mixtures of nonglycopeptides at a 1:100 molar ratio), and reproducibility (CVs < 20%) are also dramatically improved."

According to the news editors, the research concluded: "We have successfully profiled the N-glycoproteome from only 1 mu L, of human colorectal cancer serum using this innovative protocol, which offers a more efficient alternative N-glycoproteome extraction method."

For more information on this research see: Highly Selective and Ultra Fast Solid-Phase Extraction of N-Glycoproteome by Oxime Click Chemistry Using Aminooxy-Functionalized Magnetic Nanoparticles. Analytical Chemistry, 2014;86(15):7920-7924. Analytical Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Analytical Chemistry - www.pubs.acs.org/journal/ancham)

The news correspondents report that additional information may be obtained from Y. Zhang, Fudan University, Adv Mat Lab, Dept. of Macromol Sci, Shanghai 200433, People's Republic of China. Additional authors for this research include M. Yu, C. Zhang, W.F. Ma, Y.T. Zhang, C.C. Wang and H.J. Lu (see also Magnetic Nanoparticles).

Keywords for this news article include: Shanghai, People's Republic of China, Asia, Chemicals, Chemistry, Emerging Technologies, Magnetic Nanoparticles, Nanotechnology

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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