New Findings from Myongji University in the Area of Connective Tissue Cells Described (Role of surface modification in zinc oxide nanoparticles and its toxicity assessment toward human dermal fibroblast cells)
By a News Reporter-Staff News Editor at Life Science Weekly -- Fresh data on Connective Tissue Cells are presented in a new report. According to news originating from Yongin, South Korea, by NewsRx correspondents, research stated, "The wide-scale applications of zinc oxide (ZnO) nanoparticles (NPs) in photocatalysts, gas sensors, and cosmetics may cause toxicity to humans and environments. Therefore, the aim of the present study was to reduce the toxicity of ZnO NPs by coating them with a silica (SiO2) layer, which could be used in human applications, such as cosmetic preparations."
Our news journalists obtained a quote from the research from Myongji University, "The sol-gel method was used to synthesize core ZnO with SiO2-shelled NPs (SiO2/ZnO NPs) with varying degrees of coating. Diverse studies were performed to analyze the toxicity of NPs against cells in a dose-and time-dependent manner. To ensure the decreased toxicity of the produced SiO2/ZnO NPs, cytotoxicity in membrane damage and/or intracellular reactive oxygen species (ROS) were assessed by employing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, lactate dehydrogenase, 2',7'-dichlorofluorescin, and lipid peroxide estimations. The cores of ZnO NPs exhibited cytotoxicity over time, regardless of shell thickness. Nevertheless, the thicker SiO2/ZnO NPs revealed reduced enzyme leakage, decreased peroxide production, and less oxidative stress than their bare ZnO NPs or thinner SiO2/ZnO NPs."
According to the news editors, the research concluded: "Therefore, thicker SiO2/ZnO NPs moderated the toxicity of ZnO NPs by restricting free radical formation and the release of zinc ions, and decreasing surface contact with cells."
For more information on this research see: Role of surface modification in zinc oxide nanoparticles and its toxicity assessment toward human dermal fibroblast cells. International Journal of Nanomedicine, 2014;9():3707-3718. International Journal of Nanomedicine can be contacted at: Dove Medical Press Ltd, PO Box 300-008, Albany, Auckland 0752, New Zealand (see also Connective Tissue Cells).
The news correspondents report that additional information may be obtained from M. Ramasamy, Myongji University, Dept. of Chem, Yongin, South Korea. Additional authors for this research include M. Das, S.S.A. An and D.K. Yi.
Keywords for this news article include: Yongin, South Korea, Asia, Chemicals, Chemistry, Connective Tissue Cells, Emerging Technologies, Fibroblasts, Nanoparticle, Nanotechnology, Zinc Compounds, Zinc Oxide
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC