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New Findings from Massachusetts Institute of Technology Describe Advances in DNA Research (Cell-Based Biosensor to Report DNA Damage in Micro- and...

September 10, 2014



New Findings from Massachusetts Institute of Technology Describe Advances in DNA Research (Cell-Based Biosensor to Report DNA Damage in Micro- and Nanosystems)

By a News Reporter-Staff News Editor at Biotech Week -- New research on DNA Research is the subject of a report. According to news reporting originating from Cambridge, Massachusetts, by NewsRx correspondents, research stated, "Understanding how newly engineered micro- and nanoscale materials and systems that interact with cells impact cell physiology is crucial for the development and ultimate adoption of such technologies. Reports regarding the genotoxic impact of forces applied to cells in such systems that can both directly or indirectly damage DNA emphasize the need for developing facile methods to assess how materials and technologies affect cell physiology."

Our news editors obtained a quote from the research from the Massachusetts Institute of Technology, "To address this need we have developed a TurboRFP-based DNA damage reporter cell line in NIH-3T3 cells that fluoresce to report genotoxic stress caused by a wide variety of agents, from chemical genotoxic agents to UV-C radiation. Our biosensor was successfully implemented in reporting the genotoxic impact of nanomaterials, demonstrating the ability to assess size dependent geno- and cyto-toxicity. The biosensor cells can be assayed in a high throughput, noninvasive manner, with no need for overly sophisticated equipment or additional reagents."

According to the news editors, the research concluded: "We believe that this open-source biosensor is an important resource for the community of micro- and nanomaterials and systems designers and users who wish to evaluate the impact of systems and materials on cell physiology."

For more information on this research see: Cell-Based Biosensor to Report DNA Damage in Micro- and Nanosystems. Analytical Chemistry, 2014;86(15):7598-7605. Analytical Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Analytical Chemistry - www.pubs.acs.org/journal/ancham)

The news editors report that additional information may be obtained by contacting A. Fendyur, MIT, Dept. of Elect Engn & Comp Sci, Cambridge, MA 02139, United States. Additional authors for this research include S. Varma, C.T. Lo and J. Voldman (see also DNA Research).

Keywords for this news article include: Cambridge, Massachusetts, United States, North and Central America, Bioengineering, Bionanotechnology, Biosensing, Biotechnology, DNA Damage, DNA Research, Deoxyribonucleic Acid, Emerging Technologies, Nanobiotechnology, Nanomaterial, Nanosystems, Nanotechnology, Proteomics, Technology

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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