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New Chemical Sensors and Actuators Study Findings Have Been Reported by Investigators at CSEM (Real time optical immunosensing with flow-through...

September 9, 2014

New Chemical Sensors and Actuators Study Findings Have Been Reported by Investigators at CSEM (Real time optical immunosensing with flow-through porous alumina membranes)

By a News Reporter-Staff News Editor at Life Science Weekly -- Research findings on Chemical Sensors and Actuators are discussed in a new report. According to news originating from Alpnach, Switzerland, by NewsRx correspondents, research stated, "Through the presentation of analytical data from bioassay experiments, measured by polarimetry, we demonstrate for the first time a real time immunoassay within a free standing macroporous alumina membrane. The 200 nm nominal pore diameter of the membrane enables flow-through, thereby providing an ideal fluidic platform for the targeted delivery of analytes to bioreceptors immobilized on the pore walls, enabling fast sensing response times and the use of small sample volumes (

Our news journalists obtained a quote from the research from CSEM, "For the immunoassay, the pore walls were first coated with the functional copolymer, copoly(DMA-NAS) using a novel coupling process, before immobilization of the allergen protein, beta-lactoglobulin, by spotting. The immuno-assay then proceeded with the binding of the primary and secondary antibody cognates, rabbit anti-beta-lactoglobulin and anti-rabbit IgG respectively."

According to the news editors, the research concluded: "Through the use of streptavidin coated quantum dots as refractive index signal enhancers, a noise floor for individual measurements of 3.7 ng/mL (25 pM) was obtained, with an overall statistical, or formal assay LOD of 33.7 ng/mL (225 pM), for total assay time below 1 h."

For more information on this research see: Real time optical immunosensing with flow-through porous alumina membranes. Sensors and Actuators B-Chemical, 2014;202():834-839. Sensors and Actuators B-Chemical can be contacted at: Elsevier Science Sa, PO Box 564, 1001 Lausanne, Switzerland (see also Chemical Sensors and Actuators).

The news correspondents report that additional information may be obtained from J. Alvarez, Cent Switzerland Center, CSEM SA, CH-6055 Alpnach, Switzerland. Additional authors for this research include L. Sola, M. Cretich, M.J. Swann, K.B. Gylfason, T. Volden, M. Chiari and D. Hill.

Keywords for this news article include: Alpnach, Switzerland, Europe, Chemical Sensors and Actuators

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Source: Life Science Weekly

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