Investigators from Wuhan University of Technology Report New Data on Nanoparticles (pH/redox responsive core cross-linked nanoparticles from thiolated carboxymethyl chitosan for in vitro release study of methotrexate)
By a News Reporter-Staff News Editor at Cancer Weekly -- Research findings on Nanoparticles are discussed in a new report. According to news originating from Wuhan, People's Republic of China, by NewsRx correspondents, research stated, "A novel amphiphilic thiolated carboxymethyl chitosan was synthesized. It self-assembled into disulfide bond cross-linked nanoparticles in deionized water."
Our news journalists obtained a quote from the research from the Wuhan University of Technology, "The TEM showed that these nanoparticles had a core-shell structure with an average diameter of 160nm. Dynamic light scattering showed that the nanoparticles were stable in water solution. The particle size changed with pH values and GSH concentrations, and reached a maximum diameter at pH 7.0 and 20 mM GSH respectively, exhibiting an obvious pH/redox responsibility. Methotrexate was encapsulated in nanoparticles reaching encapsulation efficiency as much as 43.4%. Release profiles of methotrexate showed a release rate of 19 wt% in pH 7.4 buffer containing 10 mu M GSH, whereas as high as 93 wt% in pH 5.0 buffer containing 20 mM GSH, indicating that the nanoparticles may be used for tumor-specific drug release."
According to the news editors, the research concluded: "The anticancer activity test in vitro showed that the inhibition rate of methotrexate-loaded nanoparticles against HeLa cells reached 90%."
For more information on this research see: pH/redox responsive core cross-linked nanoparticles from thiolated carboxymethyl chitosan for in vitro release study of methotrexate. Carbohydrate Polymers, 2014;111():964-970. Carbohydrate Polymers can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Carbohydrate Polymers - www.elsevier.com/wps/product/cws_home/405871)
The news correspondents report that additional information may be obtained from C. Gao, Wuhan Univ Technol, Sch Chem Engn, Dept. of Pharmaceut Engn, Wuhan 430070, People's Republic of China. Additional authors for this research include T. Liu, Y.H. Dang, Z.Y. Yu, W. Wang, J.J. Guo, X.Q. Zhang, G.H. He, H. Zheng, Y.H. Yin and X.Q. Kong (see also Nanoparticles).
Keywords for this news article include: Wuhan, People's Republic of China, Asia, Emerging Technologies, Nanoparticle, Nanoparticles, Nanotechnology
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