Investigators from University of Maryland Target Anions (Antibacterial activity and ion release of bonding agent containing amorphous calcium phosphate nanoparticles)
By a News Reporter-Staff News Editor at Biotech Week -- Researchers detail new data in Anions. According to news reporting originating in Baltimore, Maryland, by NewsRx journalists, research stated, "Recurrent caries at the margins is a primary reason for restoration failure. The objectives of this study were to develop bonding agent with the double benefits of antibacterial and remineralizing capabilities, to investigate the effects of NACP filler level and solution pH on Ca and P ion release from adhesive, and to examine the antibacterial and dentin bond properties."
The news reporters obtained a quote from the research from the University of Maryland, "Nanoparticles of amorphous calcium phosphate (NACP) and a quaternary ammonium monomer (dimethylaminododecyl methacrylate, DMADDM) were synthesized. Scotchbond Multi-Purpose (SBMP) primer and adhesive served as control. DMADDM was incorporated into primer and adhesive at 5% by mass. NACP was incorporated into adhesive at filler mass fractions of 10%, 20%, 30% and 40%. A dental plaque microcosm biofilm model was used to test the antibacterial bonding agents. Calcium (Ca) and phosphate (P) ion releases from the cured adhesive samples were measured vs. filler level and solution pH of 7, 5.5 and 4. Adding 5% DMADDM and 10-40% NACP into bonding agent, and water-aging for 28 days, did not affect dentin bond strength, compared to SBMP control at 1 day (p > 0.1). Adding DMADDM into bonding agent substantially decreased the biofilm metabolic activity and lactic acid production. Total microorganisms, total streptococci, and mutans streptococci were greatly reduced for bonding agents containing DMADDM. Increasing NACP filler level from 10% to 40% in adhesive increased the Ca and P ion release by an order of magnitude. Decreasing solution pH from 7 to 4 increased the ion release from adhesive by 6-10 folds. Signcance. Bonding agents containing antibacterial DMADDM and remineralizer NACP were formulated to have Ca and P ion release, which increased with NACP filler level from 10% to 40% in adhesive. NACP adhesive was 'smart' and dramatically increased the ion release at cariogenic pH 4, when these ions would be most-needed to inhibit caries."
According to the news reporters, the research concluded: "Therefore, bonding agent containing DMADDM and NACP may be promising to inhibit biofilms and remineralize tooth lesions thereby increasing the restoration longevity."
For more information on this research see: Antibacterial activity and ion release of bonding agent containing amorphous calcium phosphate nanoparticles. Dental Materials, 2014;30(8):891-901. Dental Materials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Dental Materials - www.elsevier.com/wps/product/cws_home/601024)
Our news correspondents report that additional information may be obtained by contacting C. Chen, University of Maryland, Dept. of Mech Engn, Baltimore, MD 21250, United States. Additional authors for this research include M.D. Weir, L. Cheng, N.J. Lin, S. Lin-Gibson, L.C. Chow, X.D. Zhou and H.H.K. Xu (see also Anions).
Keywords for this news article include: Baltimore, Maryland, United States, North and Central America, Anions, Calcium Compounds, Calcium Phosphates, Dentistry, Emerging Technologies, Inorganic Chemicals, Nanoparticle, Nanotechnology, Phosphoric Acids, Phosphorus Compounds
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