Findings on Stem Cells Detailed by Investigators at University of British Columbia (Effects of Silica and Titanium Oxide Particles on a Human Neural Stem Cell Line: Morphology, Mitochondrial Activity, and Gene Expression of Differentiation ...)
By a News Reporter-Staff News Editor at Stem Cell Week -- New research on Stem Cell Research is the subject of a report. According to news reporting originating in Vancouver, Canada, by NewsRx journalists, research stated, "Several in vivo studies suggest that nanoparticles (smaller than 100 nm) have the ability to reach the brain tissue. Moreover, some nanoparticles can penetrate into the brains of murine fetuses through the placenta by intravenous administration to pregnant mice."
The news reporters obtained a quote from the research from the University of British Columbia, "However, it is not clear whether the penetrated nanoparticles affect neurogenesis or brain function. To evaluate its effects on neural stem cells, we assayed a human neural stem cell (hNSCs) line exposed in vitro to three types of silica particles (30 nm, 70 nm, and = 0.1 mg/mL for 7 days. Moreover, all the particles affected the gene expression of Nestin (stem cell marker) and neurofilament heavy polypeptide (NF-H, neuron marker) at 0.1 mg/mL. In contrast, only 30-nm silica particles at 1.0 mg/mL significantly reduced mitochondrial activity."
According to the news reporters, the research concluded: "Notably, 30-nm silica particles exhibited acute membrane permeability at concentrations >= 62.5 mu g/mL in 24 h. Although these concentrations are higher than the expected concentrations of nanoparticles in the brain from in vivo experiments in a short period, these thresholds may indicate the potential toxicity of accumulated particles for long-term usage or continuous exposure."
For more information on this research see: Effects of Silica and Titanium Oxide Particles on a Human Neural Stem Cell Line: Morphology, Mitochondrial Activity, and Gene Expression of Differentiation Markers. International Journal of Molecular Sciences, 2014;15(7):11742-11759. International Journal of Molecular Sciences can be contacted at: Mdpi Ag, Postfach, Ch-4005 Basel, Switzerland (see also Stem Cell Research).
Our news correspondents report that additional information may be obtained by contacting K. Fujioka, University of British Columbia, Dept. of Med, Div Neurol, Vancouver, BC V6T 2B5, Canada. Additional authors for this research include S. Hanada, Y. Inoue, K. Sato, K. Hirakuri, K. Shiraishi, F. Kanaya, K. Ikeda, R. Usui, K. Yamamoto, S.U. Kim and Y. Manome.
Keywords for this news article include: Vancouver, British Columbia, Canada, North and Central America, Emerging Technologies, Light Metals, Nanoparticle, Nanotechnology, Stem Cell Research, Titanium
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