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Findings on Peptides and Proteins Detailed by Investigators at University of Prince Edward Island (Isolation and Structure Elucidation of...

September 12, 2014



Findings on Peptides and Proteins Detailed by Investigators at University of Prince Edward Island (Isolation and Structure Elucidation of Cystargamide, a Lipopeptide from Kitasatospora cystarginea)

By a News Reporter-Staff News Editor at Drug Week -- Investigators discuss new findings in Peptides. According to news reporting originating from Charlottetown, Canada, by NewsRx correspondents, research stated, "A new lipopeptide, cystargamide (1) was isolated from the fermentation broth of the actinomycete Kitasatospora cystarginea."

Our news editors obtained a quote from the research from the University of Prince Edward Island, "The bacterial strain was selected from a set of 12 Kitasatospora spp. using a secondary metabolomics approach combining liquid chromatography/high-resolution mass spectrometry (LC-HRMS) with principal component analysis (PCA). Cystargamide (1) was purified by reversed-phase HPLC, and the structure elucidation was achieved by interpreting mass spectrometry and NMR data."

According to the news editors, the research concluded: "Cystargamide (1) contains rare structural features including a 5-hydroxy tryptophan residue and a 2,3-epoxydecanoyl fatty acid group."

For more information on this research see: Isolation and Structure Elucidation of Cystargamide, a Lipopeptide from Kitasatospora cystarginea. Journal of Natural Products, 2014;77(6):1372-1376. Journal of Natural Products can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Journal of Natural Products - www.pubs.acs.org/journal/jnprdf)

The news editors report that additional information may be obtained by contacting K.A. Gill, University of Prince Edward Island, Dept. of Biomed Sci, Atlantic Vet College, Charlottetown, PE C1A 4P3, Canada. Additional authors for this research include F. Berrue, J.C. Arens and R.G. Kerr (see also Peptides).

Keywords for this news article include: Charlottetown, Prince Edward Island, Canada, North and Central America, Lipopeptides

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Drug Week


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