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Findings on Nanoparticles Reported by S. Perez-Rentero et al (Thioctic Acid Derivatives as Building Blocks to Incorporate DNA Oligonucleotides onto...

September 9, 2014



Findings on Nanoparticles Reported by S. Perez-Rentero et al (Thioctic Acid Derivatives as Building Blocks to Incorporate DNA Oligonucleotides onto Gold Nanoparticles)

By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on Nanoparticles is now available. According to news reporting out of Barcelona, Spain, by NewsRx editors, research stated, "Oligonucleotide gold nanoparticle conjugates are being used as diagnostic tools and gene silencing experiments. Thiol-chemistry is mostly used to functionalize gold nanoparticles with oligonucleotides and to incorporate DNA or RNA molecules onto gold surfaces."

Our news journalists obtained a quote from the research, "However, the stability of such nucleic acid-gold nanoparticle conjugates in certain conditions may be a limitation due to premature break of the thiol-gold bonds followed by aggregation processes. Here, we describe a straightforward synthesis of oligonucleotides carrying thioctic acid moiety based on the use of several thioctic acid-L-threoninol derivatives containing different spacers, including triglycine, short polyethyleneglycol, or aliphatic spacers. The novel thioctic-oligonucleotides were used for the functionalization of gold nanoparticles and the surface coverage and stability of the resulting thioctic-oligonucleotide gold nanoparticles were assessed. In all cases gold nanoparticles functionalized with thioctic-oligonucleotides had higher loadings and higher stability in the presence of thiols than gold nanoparticles prepared with commercially available thiol-oligonucleotides. Furthermore, the thioctic derivative carrying the triglycine linker is sensitive to cathepsin B present in endosomes."

According to the news editors, the research concluded: "In this way this derivative may be interesting for the cellular delivery of therapeutic oligonucleotides as these results provides the basis for a potential endosomal escape."

For more information on this research see: Thioctic Acid Derivatives as Building Blocks to Incorporate DNA Oligonucleotides onto Gold Nanoparticles. Molecules, 2014;19(7):10495-10523. Molecules can be contacted at: Mdpi Ag, Postfach, Ch-4005 Basel, Switzerland. (Springer - www.springer.com; Molecules - www.springerlink.com/content/1420-3049/)

Our news journalists report that additional information may be obtained by contacting S. Perez-Rentero, Networking Center Bioengn Biomat & Nanomed CIBER BBN, Barcelona 08034, Spain. Additional authors for this research include S. Grijalvo, G. Penuelas, C. Fabrega and R. Eritja (see also Nanoparticles).

Keywords for this news article include: Barcelona, Spain, Europe, Emerging Technologies, Gold Nanoparticles, Nanotechnology

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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