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Findings from University of Pennsylvania Broaden Understanding of Estradiol Congeners (Estradiol regulates markers of synaptic plasticity in the...

September 10, 2014



Findings from University of Pennsylvania Broaden Understanding of Estradiol Congeners (Estradiol regulates markers of synaptic plasticity in the hypothalamic ventromedial nucleus and amygdala of female rats)

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Hormones. According to news reporting out of Philadelphia, Pennsylvania, by NewsRx editors, research stated, "Ovarian hormones act in multiple brain regions to modulate specific behaviors and emotional states. For example, ovarian hormones promote female sexual receptivity in the hypothalamic ventromedial nucleus (VMH) and modulate anxiety in the amygdala."

Our news journalists obtained a quote from the research from the University of Pennsylvania, "Hormone-induced changes within the VMH include structural modifications, such as changes in dendritic spines, dendrite length and the number of synapses. In some situations, dendrite remodeling requires actin polymerization, which depends on phospho-deactivation of the enzyme cofilin, or the ionotropic AMPA-type glutamate receptors, especially the GluA1 and GluA2 subunits. The present experiments used immunohistochemistry to test the hypothesis that ovarian hormone-induced neural plasticity in the VMH and amygdala involves the regulation of phospho-cofilin, GluA1 and GluA2. These proteins were assessed acutely after estradiol administration (0.5, 1.0 and 4.0 h), as well as three days after hormone treatment. Both brain regions displayed rapid (4.0 h or less) and transient estradiol-induced increases in the level of phospho-cofilin. At the behaviorally relevant time point of three days, differential changes in AMPA receptor subunits were observed. Using Golgi impregnation, the effect of estradiol on amygdala dendrites was examined. Three days after estradiol treatment, an increase in the length of dendrites in the central nucleus of the amygdala was observed."

According to the news editors, the research concluded: "Thus, estradiol initiates structural changes in dendrites in both the VMH and amygdala associated with an early phospho-deactivation of cofilin, followed by dynamic, brain region-specific changes in AMPA receptor composition."

For more information on this research see: Estradiol regulates markers of synaptic plasticity in the hypothalamic ventromedial nucleus and amygdala of female rats. Hormones and Behavior, 2014;66(2):409-420. Hormones and Behavior can be contacted at: Academic Press Inc Elsevier Science, 525 B St, Ste 1900, San Diego, CA 92101-4495, USA. (Elsevier - www.elsevier.com; Hormones and Behavior - www.elsevier.com/wps/product/cws_home/622842)

Our news journalists report that additional information may be obtained by contacting S.L. Ferri, University of Pennsylvania, David Mahoney Inst Neurol Sci, Philadelphia, PA 19104, United States. Additional authors for this research include P.F. Hildebrand, S.E. Way and L.M. Flanagan-Cato (see also Hormones).

Keywords for this news article include: Philadelphia, Pennsylvania, United States, North and Central America, Amygdala, Basal Ganglia, Brain, Estradiol Congeners, Gonadal Hormones, Limbic System, Prosencephalon, Telencephalon

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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