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Findings from Sun Yat Sen University Broaden Understanding of Pain (Antinociceptive Effect of Intrathecal Microencapsulated Human Pheochromocytoma...

September 10, 2014



Findings from Sun Yat Sen University Broaden Understanding of Pain (Antinociceptive Effect of Intrathecal Microencapsulated Human Pheochromocytoma Cell in a Rat Model of Bone Cancer Pain)

By a News Reporter-Staff News Editor at Biotech Week -- Researchers detail new data in Neurologic Manifestations. According to news reporting originating in Guangzhou, People's Republic of China, by NewsRx journalists, research stated, "Human pheochromocytoma cells, which are demonstrated to contain and release met-enkephalin and norepinephrine, may be a promising resource for cell therapy in cancer-induced intractable pain. Intrathecal injection of alginate-poly (L) lysine-alginate (APA) microencapsulated human pheochromocytoma cells leads to antinociceptive effect in a rat model of bone cancer pain, and this effect was blocked by opioid antagonist naloxone and alpha 2-adrenergic antagonist rauwolscine."

The news reporters obtained a quote from the research from Sun Yat Sen University, "Neurochemical changes of cerebrospinal fluid are in accordance with the analgesic responses. Taken together, these data support that human pheochromocytoma cell implant-induced antinociception was mediated by met-enkephalin and norepinephrine secreted from the cell implants and acting at spinal receptors."

According to the news reporters, the research concluded: "Spinal implantation of microencapsulated human pheochromocytoma cells may provide an alternative approach for the therapy of chronic intractable pain."

For more information on this research see: Antinociceptive Effect of Intrathecal Microencapsulated Human Pheochromocytoma Cell in a Rat Model of Bone Cancer Pain. International Journal of Molecular Sciences, 2014;15(7):12135-12148. International Journal of Molecular Sciences can be contacted at: Mdpi Ag, Postfach, Ch-4005 Basel, Switzerland (see also Neurologic Manifestations).

Our news correspondents report that additional information may be obtained by contacting X. Li, Sun Yat Sen UniversitySun Yat Sen Mem Hosp, Dept. of Cardiol, Guangzhou 510120, People's Republic of China. Additional authors for this research include G.Q. Li, S.L. Wu, B.Y. Zhang, Q. Wan, D. Yu, R.J. Zhou and C. Ma.

Keywords for this news article include: Guangzhou, People's Republic of China, Asia, Antinociceptive, Bone Research, Cancer, Nervous System Diseases, Neurologic Manifestations, Oncology, Pain Medicine

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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