Our news journalists obtained a quote from the research, "Thermosensitive injectable hydrogel composed of nanoparticles assembled from amphiphilic copolymer poly(epsilon-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-undecanone)-poly(ethylene glycol)-poly(scaprolaone-co-1,4,8-trioxa[4.6]spiro-9-undecanone) (PECT) was fabricated. Hydrophobic PTX and hydrophilic DOX.HCl were loaded simultaneously in the thermo-sensitive injectable hydrogel by a two-stage entrapment. Thermosensitive gelling behaviors of drug-loading PECT nanoparticle aqueous dispersions were studied. In vitro release profiles of PTX and DOX.HCl and in vivo anti-tumor effect by dual drugs from PECT hydrogel were investigated. The results showed that hydrophilic and hydrophobic drugs could be successfully entrapped in PECT hydrogel simultaneously without affecting its thermo-sensitive behavior. In vitro release profiles demonstrated the burst release of DOX.HCl and the sustained release of PTX. Antitumor effect was improved by a fast and tense attack caused by the burst release of hydrophilic DOX'HCI from hydrogel, which was continued by the sequent sustained release of PTX-incorporated nanoparticles and remnant DOX.HCl."
According to the news editors, the research concluded: "Unintentionally, entrapped in PECT hydrogel, hydrophilic DOX.HCl was observed to have a sustained releasing pattern in vitro and in vivo."
For more information on this research see: Sustained release of PTX-incorporated nanoparticles synergized by burst release of DOX.HCl from thermosensitive modified PEG/PCL hydrogel to improve anti-tumor efficiency.
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